高龄老年人应用他汀类药物的疗效及安全性观察被引量：14

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摘要目的探讨他汀类药物在高龄老年人中应用的疗效及安全性。方法选择90例急性冠脉综合征(ACS)的高龄老年患者,随机分为治疗组50例和对照组40例。在治疗原发病的基础上,治疗组给予辛伐他汀20 mg/d,对照组给予辛伐他汀60 mg/d。2组均随访1年,观察患者随访结束低密度脂蛋白胆固醇(LDL-C)达标率及不良反应的发生率。结果2组病例LDL-C达标率比较差异无统计学意义(P>0.05),不良反应发生率比较差异有统计学意义(P<0.05)。结论对老年患者进行血脂干预时要注意辛伐他汀的用量。

作者吕玉红李然

机构地区河北省保定市第二中心医院

出处《河北医药》 CAS 2010年第5期556-557,共2页 Hebei Medical Journal

关键词辛伐他汀冠状动脉疾病老年人

分类号 R543.12 [医药卫生—心血管疾病]

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参考文献4

1张蔚.他汀类药物治疗高脂血症的临床应用[J].新医学,2007,38(5):330-331. 被引量：22
2连晓芳,孙琪,闫书彩,杨雁.高血压患者应用他汀类药物的心脏保护作用[J].河北医药,2009,31(8):997-998. 被引量：6
3胡大一,马长生主编.心脏病学实践.第1版.北京:人民卫生出版社,2007.363-378.
4许富康,郭航远,邢杨波.他汀类药物治疗扩张型心肌病心力衰竭的临床依据和可能机制的研究进展[J].中国全科医学,2008,11(4):320-322. 被引量：28

二级参考文献26

1吕瑞娟,张运,陈玉国,孙袆,王文君.他汀类药物治疗ALT升高的急性冠状动脉综合征的可行性研究[J].新医学,2006,37(6):368-369. 被引量：16
2Gang CHENG,Geng XU,Hong-wen CAI,Hui-hua WANG,Xiao-feng BAO.Effect of atorvastatin on non-ischemic heart failure and matrix metalloproteinase-2 and 9 in rats[J].Acta Pharmacologica Sinica,2007,28(4):511-517. 被引量：7
3Mac Mallon S,Peto R,Culter J,et a1.Blood pressue,stroke an dcomnary heart disease.Part 1,prolonged diferences in blood pressure:prospective observational studies corrected for the regression dilution bias.Lancet,1990,335:765-774.
4Laufs U,Fata VL,Liao JK,et al.Inhibition of 3-hydroxy-3-methyl ghuraryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase.J Biol Chem,1997,272:31725-31729.
5Wolfrum S,Jensen KS,Liao JK.Endothelium-dependent effects of statins.Arterioscler Thromb Vasc Biol,2003,23:729-736.
6Mraiche F,Cena J,Das D,et al.Effects of statins on vascularfunction of endothelin-1.Br J Pharmacol,2005,144:715-726.
7Sugiyama M,Ohashi M,Takase H,et al.Effects of atorvastain on inflam -mation and oxidative stressls.Heart Vessels,2005,4:133-136.
8Madamanchi NR,Hakim ZS,Runge MS.Oxidative stress in atherogenesis and arterial thrombosis:the disconnected between cellular studies and clinical outcomes.J Thromb Haemost,2005,3:254-267.
9Bonnie Ky,Anne Burke,Sotirios Tsimikas,et al.The influence of simvastatin and Atorvastatin on markers of oxidative stress in hypercholesterolemic humans.J Am Coll Cardiol,2008,51:1653-l662.
10Wassmann S,Laufs U,Baumer AT,et al.HMG-CoA reductase inhibitors improve endothelial dysfunction in normoeholesterelemic hypcrtcnsion via reduced production of reactive oxygen species.Hypertension,2001,37:1450-1457.