一组新的光学活性脂肪族β-氨基醇的合成

SYNTHESIS OF A NEW SERIES OF CHIRAL ALIPHATIC β AMINO ALCOHOLS

手性口恶唑硼烷催化的前手性酮对映选择性硼烷还原已成为合成光学活性二级醇的最重要方法之一。此类催化剂可由相应的手性氨基醇得到。为研究这类催化剂结构与性能的关系，我们设计合成了一组新的光学活性脂肪族β－氨基醇。这些氨基醇的结构特点是分子中有一个叔丁基通过若干个亚甲基构成的不同长度“臂”连在手性碳上。本文报道这些氨基醇的合成。

The enantioselective borane reduction of prochiral ketones catalyzed by chiral oxazaborolidines has been developed as one of the most important methods for the preparation of optically active secondary alcohols.The catalysts can be obtained from the related chiral amino alcohols.For investigation of the structure activity relationships of this kind of catalysts,we designed and prepared a new series of chiral aliphatic β amino alcohols.Each of them has a tert butyl group attached to the chiral centre through a (CH 2) n chain (n=2,3,4 or 5).This paper reports the syntheses of these amino alcohols.