荧光法研究 Ge-132 对苯丙氨酸 Maillard 反应的抑制作用

Fluorescence Spectrometric Study on the Suppression of Ge132 on Maillard Reaction of Phenylalanine

哺乳动物体内氨基酸及蛋白质的非酶糖化反应（Ｍａｉｌａｒｄ反应）与糖尿病及其并发症的关系已引起广泛关注［１］，β－羧乙基锗倍半氧化物（Ｇｅ－１３２）具有预防糖尿病和调节糖代谢的作用［２］，研究Ｇｅ－１３２对Ｍａｉｌａｒｄ反应的抑制作用对于开发防治糖尿病...

It has been observed that em of phenylalanine and glycosylated phenylalanine in fluoresce spectra are 2810 nm and 440 nm, respectively, that permits to investigate the suppression of Ge132 on the Maillard reaction of phenylalanine without any interference. The result shows that the fluorescence intensity(FI) of glycosylated phenylalanine increases continuously with the decrease of FI of phenylalanine, and Ge132 exhibits a suppression on the Maillard reaction of phenylalanine up to 423%.