生物合理设计光系统Ⅱ抑制剂研究(Ⅴ)──取代苯甲酰胺基丙烯酸乙酯和新型嘧啶酮类化合物的合成及其Hil反应抑制活性

 Studies on Bio rational Design of Photosystem Ⅱ Inhibitors(Ⅴ)----Synthesis and Hill Inhibitory Activities of Ethyl Arylamideacrylates and Pyrimidone

基于Ｄ１蛋白结构模型，设计并合成了取代苯甲酰胺基丙烯酸乙酯及有关成环化合物嘧啶酮，通过Ｘ射线衍射确定了２－芳基－５－乙氧甲酰基－６－甲硫基－４－嘧啶酮的结构．生物活性测定结果表明，部分化合物显示出一定的Ｈｉｌ反应抑制活性．

Based on targets structure and using bio rational molecular design, the title compounds have been designed and synthesized. The structure of pyrimidone 3a was confirmed by X ray. Their Hill inhibitory activities were tested, and it was found that some of them showed good inhibition.