期刊文献+

妊娠相关血浆蛋白-A与颈动脉粥样硬化斑块及缺血性脑血管病的关系 被引量:11

Relationship between pregnancy-associated plasma protein-A and carotid atherosclerotic plaque and ischemic cerebrovascular disease
下载PDF
导出
摘要 目的探讨血清妊娠相关血浆蛋白(PAPP)-A与颈动脉粥样硬化斑块及缺血性脑血管病(ICVD)的关系。方法116例首次发生颈内动脉系统ICVD的住院患者,包括急性脑梗死(ACI)72例和短暂性脑缺血发作(TIA)44例,另选38例体检者(对照组),均行头颅CT、颈动脉彩色多普勒超声仪及血清PAPP-A检查;根据颈动脉彩色多普勒超声仪检查结果,按斑块性质分为易损斑块组(39例)、稳定斑块组(60例)、内-中膜增厚组(20例)及无斑块组(35例),并对各项检查结果进行组间比较。结果血清PAPP-A水平,ACI组[(5.64±1.92)mIU/L]及TAI组[(5.51±2.01)mIU/L]明显高于对照组[(4.12±1.98)mIU/L](均P<0.05);各组中易损斑块组的血清PAPP-A水平明显高于无斑块组、内-中膜增厚组及稳定斑块组(均P<0.05)。PAPP-A对易损斑块、ACI、TIA的诊断评估显示曲线下面积(AUC)分别为0.87、0.61及0.57。结论血清PAPP-A水平可作为诊断颈动脉粥样硬化易损斑块存在的生物学标记物,其血清水平的升高可视为ICVD的危险因素之一。 Objective To investigate the relationship between pregnancy-associated plasma protein(PAPP-A)and carotid atherosclerotic plaque and ischemic cerebrovascular disease(ICVD).Methods 116 patients with first onset of ICVD in carotid artery system,including 72 cases with acute cerebral infarction(ACI group)and 44 cases with transient ischemic attck(TIA group),and 38 subjects(control group)were detected by craniocerebral CT and carotid color Doppler ultrasonography.And the serum PAPP-A of them were also be measured.According to carotid color Doppler ultrasound,the ICVD patients were divided into vulnerable plaque group(39 cases),stable plaque group(60 cases),intima-media thickened group(20 cases)and no plaque group(35 cases).And the results of them were compared with each group.Results The levels of serum PAPP-A of ACI group[(5.64±1.92)mIU/L]and TIA group[(5.51±2.01)mIU/L]were both significantly higher than control group[(4.12±1.98)mIU/L](all P〈0.05).In each group,the level of serum PAPP-A of vulnerable plaque group was significantly higher than no plaque group,intima-media thickened group and stable plaque group(all P〈0.05).The diagnostic assessment of PAPP-A showed the areas under the curve(AUC)on vulnerable plaque,ACI and TIA were 0.87,0.61 and 0.57.Conclusion The level of serum PAPP-A can be treated as a prediction index of carotid atherosclerotic vulnerable plaque,and the growing of which may be a risk factor of ICVD.
出处 《临床神经病学杂志》 CAS 北大核心 2010年第1期15-17,共3页 Journal of Clinical Neurology
关键词 妊娠相关血浆蛋白-A 颈动脉粥样硬化 易损斑块 缺血性脑血管病 pregnancy-associated plasma protein-A carotid arthrosclerosis vulnerable plaque ischemic cerebrovascular disease
  • 相关文献

参考文献10

  • 1Bayes Gneis A, Conover CA, Overgaard MT, et al. Pregnancy-associated plasma protein A as a marker of acute coronary syndromes[ J]. N Engl J Med, 2001, 345:1022.
  • 2Qin QP, Wittfooth S, Pettersson K, et al. Measurement and clinical significance of circulating PAPP-A in ACS patients [ J ]. Clin Chim Act, 2007, 380:59.
  • 3王拥军.应加强颈动脉粥样硬化的基础和临床研究[J].中华神经科杂志,2001,34(5):257-258. 被引量:168
  • 4Liapis CD, Kakisis JD, Kostakis AC. Carotid stenosis: factors affecting symptomatology [ J ]. Stroke, 2001,32:782.
  • 5陈东,智睿,丁朝兵,王文安.颈动脉粥样硬化斑块及其相关因素与脑梗死的关系[J].临床神经病学杂志,2007,20(6):468-470. 被引量:17
  • 6Lee DJ, Sigel B, Suami UK, et al. Determination of carotid plaque risk by uhrasonic tissue characterization [ J ]. Ultrasound Med Biol, 1998,24 : 12.
  • 7Futtermann LG, Lemberg L. Novel makers in acute coronary syndrome: BNP, IL-6, PAPP-A[J]. Am J Crit Car, 2002, 11:168.
  • 8Giuseppe S, Alessandro M, Elena B, et al. Pregnancy associated plasma protein-A is markedly expressed by monocyte-macrophage cells in vulnerable and ruptured carotid atherosclerotic plaques [ J ]. JACC, 2006,47:2201.
  • 9Balaram SK, Agrawal DK, Edwards JD. Insulin like growth factor-1 activates nuclear factor-κB and increases transcription of the intercellular adhesion molecule-1 gene in endothelial cells [ J]. Cardiovasc Surg,1999, 7: 91.
  • 10Beaudeu JL, Burc L, Imbert-Bismut F, et al. Serum pregnancy-associated plasma protein A:a potential marker of echogenic of echogenic carotid atherosclerotic plaques in asymptomatic hyperlipidemic subjects at high cardiovascular risk[J]. Arterioseler Thromb Vasc Biol, 2003, 23: 7.

二级参考文献8

  • 1刘斌,石秋艳,李玉荣,张晋霞,宁树成,伊红丽,刘昊,陈桂华.脑梗死患者颈动脉粥样硬化斑块的调查及其相关因素分析[J].中国综合临床,2004,20(11):985-987. 被引量:21
  • 2Kazmierski R, Kozubshi W, Watala C.Intima-media comlex thickness of common carotid artery as a risk factor for stroke[J].Neurol Neurochir Pol,2000,34:243.
  • 3蒲传强, 朗森阳, 吴卫平. 脑血管病学[M]. 北京: 人民军医出版社, 2001.131.
  • 4Creager MA,Luscher TF,Cosentino F,et al,Diabetes and vascular disease:pathophysiology,clinical consequences,and medical therapy:partⅠ[J].Circulation,2003,108:1527.
  • 5Ceriello A,Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance,diabetes,and cardiovascular disease?The common soil hypothesis revisited[J].Arterioscler Thromb Vasc Boil,2004,24:816.
  • 6Lankin VZ,Lisina MO,Arzamastseva NE,et al.Oxidative stress in atherooecleosis and diabetes[J].Bull Exp Boil Med,2005,140:41.
  • 7Libby P,Ridker PM, Maseri A.Inflammation and atheroclerosis CD[J]. Circulation,2002, 105: 135.
  • 8陈卓友,包仕尧.舒降之治疗脑梗死患者颈动脉粥样硬化斑块的临床研究[J].临床神经病学杂志,2004,17(1):23-25. 被引量:8

共引文献183

同被引文献91

引证文献11

二级引证文献127

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部