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Th17细胞与自身免疫性疾病 被引量：13

Th17 cell and autoimmune disease
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摘要 Th17细胞是新近发现的一种新的CD4+T细胞亚群,其分化和增殖明显不同于Th1和Th2细胞,并且在多种自身免疫性疾病中发挥了重要的作用。通过对Th17细胞及其相关因子的研究,将会揭示这类疾病的发病机制,从而为治疗自身免疫性疾病提供新的途径。 Recent studies demonstrate an IL-17-producer CD4＋ T cell subpopulation, termed Th17, distinct from Thl and Th2. Evidence suggesting that Th 17 cell play an important role in autoimmune disease. Investigating the function of Th 17 cells and related factors in autoimmune diseases could reveal the pathogenesis of these diseases and provide new methods for therapy of autoimmune diseases.
作者 梁亮 王红
机构地区 首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室
出处 《免疫学杂志》 CAS CSCD 北大核心 2010年第3期264-266,270,共4页 Immunological Journal
基金 国家自然科学基金(30400490) 北京市自然科学基金(7052023)
关键词 TH17细胞 自身免疫性疾病 Th 17 cell Autoimmune disease
分类号 R593.2 [医药卫生—内科学]
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参考文献20

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  • 2Li MO, Wan YY, Flavell RA. T cell-produced transforming growth factor-betal controls T cell tolerance and regulates T h 1- and Th 17-cell differentiation [J]. Immunity, 2007, 26 (5): 579-591.
  • 3Thakker P, Leach MW, Kuang W, et al. IL-23 is critical in the induction but not in the effector phase of experimental autoimmune encephalomyelitis[J]. J Immunol, 2007, 178 (4): 2589-2598.
  • 4Ivanov II, McKenzie BS, Zhou L, et al, The orphan nuclear receptor RORgarnmat directs the differentiation program of proinflammatory IL- 17^+ T helper cells [J]. Cell, 2006, 126 (6): 1121-1133.
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  • 8Rohn TA, Jennings GT, Hemandez M, et al. Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis[J]. Eur J Immunol, 2006, 36 (11): 2857-2867.
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免疫学杂志
2010年 第3期

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