腺苷钴胺联合经皮神经电刺激治疗老年带状疱疹后神经痛的临床观察

The clinical efficacy of combined therapy of adenosylcobalamin and transcutaneous eletrical nerve stimulation in the treatment of postherpetic neuralgia

目的:探讨腺苷钴胺联合经皮神经电刺激(TENS)治疗带状疱疹后神经痛的临床疗效。方法:选取2007年10月—2009年4月于卫生部北京医院疼痛诊疗中心就诊的带状疱疹后神经痛(PHN)患者60例,随机分为3组。A组应用TENS,B组应用腺苷钴胺,C组联合应用腺苷钴胺及TENS,疗程10d。应用视觉模拟量表(VAS)及5级评分法对疗效进行评价。结果:治疗后,联合治疗组(C组)VAS评分及5级评分均低于独立治疗组(A和B组);联合治疗组的两种评分差值均高于独立治疗组;联合治疗组有效率(100%)高于独立治疗组(65%和60%),差异均有显著性意义(P<0.05)。结论:腺苷钴胺联合TENS治疗带状疱疹后神经痛有效,可减轻疼痛程度并改善睡眠。

Objective：To study the clinical efficacy of combined therapy of adenosylcobalamin and transcutaneous eletrical nerve stimulation（TENS） in the treatment of postherpetic neuralgia（PHN）. Method： Sixty patients with PHN were randomly divided into 3 groups： group A treated with TENS, group B treated with adenosylcobalamin, group C treated with adenosylcobalamin and TENS based on the management of groups A and B. The three groups had all been treated for 10d. Result： In observation, visual analogue scale （VAS） and 5 grade pain scores of group C were lower than those of groups A and B; VAS and 5 grade pain scores differences of group C were higher than those of groups A and B; The effective rate of group C （100%） was higher than that of groups A and B respectively. The differences were significant（P〈0.05）. Conclusion： Combined therapy of adenosylcobalamin and TENS is effective for the treatment of PHN and can alleviate pain and improve sleep.