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同种异基因造血干细胞移植后血细胞嵌合状态动态检测的临床意义 被引量：4

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摘要 自1971年Thomas等首次报告同种异基因造血干细胞移植（allo-HSCT）能够使白血病患者长期存活以来,allo-HSCT已成为恶性或难治性血液病最有效的根治性治疗方法。据国际骨髓移植登记处（IBMTR）和欧洲骨髓移植协作组（EBMT）的统计结果，急性白血病第一次完全缓解（CR1）期的患者接受人类白细胞抗原（HLA）全相合同胞移植后1年的无病生存率达61％～70％，
作者 王椿 万理萍
机构地区 上海交通大学附属第一人民医院血液科
出处 《诊断学理论与实践》 2010年第1期1-5,共5页 Journal of Diagnostics Concepts & Practice
关键词 同种异基因造血干细胞移植 嵌合状态 检测
分类号 R552 [医药卫生—血液循环系统疾病]
  • 相关文献

参考文献16

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  • 2Antin JH,Childs R,Filipovich AH,et al.Establishment of complete and mixed donor chimerism after allogeneic lymphohematopoietic transplantation:recommendations from a workshop at the 2001 Tandem Meetings of the International Bone Marrow Transplant Registry and the American Society of Blood and Marrow Transplantation[J].Biol Blood Marrow Transplant,2001,7(9):473-485.
  • 3万理萍,王椿,颜式可,李大启,秦尤文,谢匡成.异基因造血干细胞移植后的嵌合状态分析[J].中华内科杂志,2006,45(6):485-488. 被引量：10
  • 4蒋瑛,万理萍,王椿,颜式可,高彦荣,姜杰玲,杨隽,蔡宇,白海涛,魏道林,谢匡成.异基因造血干细胞移植后细胞嵌合状态动态监测的临床意义[J].中华血液学杂志,2008,29(10):667-671. 被引量：9
  • 5Dubovsky J,Daxberger H,Fritsch G,et al.Kinetics of chimerism during the early post-transplant period in podiatric patients with malignant and non-malignant hematologic disorders:implications for timely detection of engraftment,graft failure and rejection[J].Leukemia,1999,13(12):2059-2069.
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二级参考文献17

  • 1万理萍,王椿,颜式可,李大启,秦尤文,谢匡成.异基因造血干细胞移植后的嵌合状态分析[J].中华内科杂志,2006,45(6):485-488. 被引量：10
  • 2Nollet F, Billict J, Selleslag D, et al. Standardisation of multiplex fluorescent short tandem repeat analysis for chimerism testing. Bone Marrow Transplant ,2001,28:511-518.
  • 3Mattsson J, Uzunel M, Brune M, et al. Mixed chimaerism is common at the time of acute graft-versus-host disease and disease response in patients receiving non-myeloablativc conditioning and allogeneic stem cell transplantation. Br J Haematol, 2001, 115: 935 -944.
  • 4McCann SR, Lawler M. Monitoring outcome: MRD; chimaerism and relapse. The EBMT hand book-haemopoietic stem cell transplantation 2004 Revised Edition. 197-212.
  • 5Mattsson J, Uzunel M, Remberger M, et al. Fraetionated TBI correlates with less T cell mixed chimerism but increased risk of relapse compared to busulphan in patients with haematological malignancies after allogeneic stem cell transplantation. Bone Marrow Transplant, 2003, 32:477-483.
  • 6Mohty M, Avinens O, Faucher C, et al. Predictive faclors and impaet of full donor T-cell chimerism after reduced intensity conditioning allogeneic stem cell transplantation. Haematologica, 2007, 92 : 1004-1006.
  • 7Miura Y, Tanaka J, Toubai T, et al. Analysis of donor-type chimerism in lineage-specific cell populations after allogeneic myeloablative and non-mveloablative stem cell transplantation. Bone Marrow Transplant, 2006,37:837-843.
  • 8Barrios M, Jimenez-Velaseo A, Roman-Gomez J, et al. Chimerism status is a useful predletor of relapse after allogeneic stem cell transplantation for acute leukemia. Haematologica, 2003, 88:801- 810.
  • 9Marks DI, Lush R, Cavenagh J, et al. The toxicity and efficaev of donor lymphocyte infusions given after reduced-intensity conditioning allogeneie stem cell transplantation. Blood, 2002, 100: 3108- 3114.
  • 10Wekerle T,Sykes M.Mixed chimerism and transplantation tolerance.Ann Rev Med,2001,52:353-370.

共引文献17

同被引文献24

  • 1李素霞,达万明,高春记,朱海燕,王书红,薄剑,靖彧,靳海杰.STR-PCR对造血干细胞移植后植入证据的检测[J].中国实验血液学杂志,2005,13(1):25-29. 被引量：6
  • 2李大启,王椿,秦尤文,张帆,谢匡成,颜式可,金力,赵寿元.异基因外周血干细胞移植后淋巴细胞和粒细胞嵌合体的动态改变[J].临床血液学杂志,2005,18(2):67-70. 被引量：8
  • 3许兰平,黄晓军.干细胞移植的HLA配型和植入证据检测[J].中国实用儿科杂志,2005,20(11):649-651. 被引量：4
  • 4万理萍,王椿,颜式可,李大启,秦尤文,谢匡成.异基因造血干细胞移植后的嵌合状态分析[J].中华内科杂志,2006,45(6):485-488. 被引量：10
  • 5孙敬芬,韩晓苹,赵丹丹,汪菲菲,靳海杰,高春记,达万明,于力.STR-PCR分析嵌合体在同种异基因造血干细胞移植中的应用[J].中国实验血液学杂志,2007,15(2):337-341. 被引量：10
  • 6Saito B, Fukuda T, Yokoyama H, et al. hnpaet of T cell chimerism on clinical outcome in 117 patients who under-went allogeneic stem cell transplantation with a busulfan- containing reduced-intensity conditioning regimen[J]. Biol Blood Marrow Transplant ,2008,14 ( 10 ) : 1148.
  • 7Ghaffari SH, Chahardouli B, Gavamzadeh A,et al. Evaluation of hematopoietic chimerism following allogeneic peripheral blood stem cell transplantation with amelogenin marker[ J ]. Arch Iran Med,2008,11( 1 ) :35.
  • 8Bornhauser M, Oelschlaegel U, Platzbecker U, et al. Monitoring of donor chimerism in sorted CD34 + peripheral blood cells allows the sensitive detection of imminent relapse after allogeneie stem cell transplantation [J]. Haematologiea, 2009,94 ( 11 ) : 1613.
  • 9Bethge WA, Faul C, Bornhauser M, et al. Haploidentical allogeneic hematopoietic cell transplantation in adults using CD3/CD19 depletion and reduced intensity conditioning: an update[J]. Blood Cells Mol Dis, 2008,40(1):13.
  • 10Thyagarajan B, Young S, Floodman S, et al. Systematic analysis of interference due to stutter in estimating chimerism following hematopoietic cell transplantation [ J ]. J Clin Lab Anal, 2009,23 ( 5 ) : 308.

引证文献4

二级引证文献6

诊断学理论与实践
2010年 第1期

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