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炎症因子与胰岛素抵抗 被引量：32

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摘要 炎症导致胰岛素抵抗（IR）的分子机制是近年的研究热点。IR使胰岛素维持正常血糖水平的能力下降，其主要发生在肝、骨骼肌和脂肪组织．对于绝大多数肥胖或2型糖尿病患者而言．其发生IR的分子机制是靶细胞胰岛素受体后信号转导通路缺陷。
作者 张豫文 洪洁
机构地区 上海交通大学医学院附属瑞金医院内分泌代谢科上海市内分泌代谢病临床医学中心上海市内分泌代谢病研究所
出处 《诊断学理论与实践》 2010年第1期90-94,共5页 Journal of Diagnostics Concepts & Practice
关键词 胰岛素抵抗 炎症因子 炎症反应
分类号 R589 [医药卫生—内分泌]
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参考文献38

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二级参考文献64

  • 1Hotta K, Funahashi T, Bodkin NL, et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes, 2001,50:1126-1133.
  • 2Daimon M, Yamaguchi H, Oizumi T, et al. Decreased scrum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese population: the Funagata study. Diabetes Care, 2003,26: 2015-2020.
  • 3Stefan N, Vozarova B, Funahsehi T,et al. Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in wholebody insulin sensitivity in humans. Diabetes,2
  • 4Stumvoll M, Tschritter O, Fritsche A, et al. Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes,2002,51:37-41.
  • 5Gustafson B, Jack MM, Cushman SW, et al. Adiponectin gene activation by thiazolidinediones requires PPAR gamma 2, but not C/EBP alpha-evidence for differential regulation of the aP2 and adiponectin genes. Biochem Biophys Res Commun,2003,308:933-939.
  • 6Pellmé F, Smith U, Funahashi T, et al. Circulating adiponectin levels are reduced in nonobese but insulin-resistant first-degree relatives of type 2 diabetic patients. Diabetes,2003,52:1182-1186.
  • 7Yamauchi T, Kamon J, Waki H, et al. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis.J Biol Chem, 2003,278: 2461-2468.
  • 8Kubota N, Terauchi Y, Yamauchi T, et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem,2002,227: 25863-25866.
  • 9Maeda N, Shimomura I, Kishida K, et al. Diet-induced insulin resistance in mice lacking adiponectin/ACR30. Nat Med,2002,8: 731-737.
  • 10Lihn AS, Ostergard T, Nyholm B, et al. Adiponectin expression in adipose tissue is reduced in first-degree relatives of type 2 diabetic patients.Am J Physiol Endocrinol Metab, 2003,284:E443-E448.

共引文献27

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引证文献32

二级引证文献160

诊断学理论与实践
2010年 第1期

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