脑心通胶囊对急性冠脉综合征患者颈动脉斑块和血清超敏C反应蛋白的影响

Effect of Naoxintong Capsule on the Carotid Plaque and Serum Hypersensit ive C-reactive Protein of the Patients with Acute Coronary Syndrome

目的探讨脑心通胶囊治疗急性冠脉综合征(ACS)的作用机制。方法将105例经冠脉造影确诊为ACS的患者随机分为治疗组55例和对照组50例,对照组给予西药常规治疗,治疗组在常规治疗基础上加服脑心痛胶囊,每次2粒,每日3次,治疗前及治疗4周后测定血清超敏C反应蛋白(hs-CRP),治疗前及治疗6个月后用彩色多普勒超声检查颈动脉内膜-中膜的厚度(IMT)及颈动脉斑块的变化。结果治疗4周后,治疗组患者血清hs-CRP含量显著低于治疗前,并且较对照组降低明显(P<0.01);治疗6个月后,治疗组患者双侧颈动脉IMT明显降低及颈动脉斑块面积明显缩小,与治疗前及对照组比较差异有统计学意义(P<0.01)。结论脑心通胶囊能有效降低ACS患者血清hs-CRP水平、改善颈动脉内膜状态、稳定颈动脉斑块,这可能是其治疗ACS的作用机理之一。

Objective To study the functional mechanism of Naoxintong Capsule （Capsule for cerebral and heart diseases） on acute coronary syndrome （ACS）. Methods Totally 105 ACS patients diagnosed with coronary angiography were randomized into a treat- ment group （55 cases）, and a control group （50 cases）. The control group was treated routinely with western medicine while the treat- ment group treated with Naoxintong Capsule, 2 capsules each time, 3 times a day, in addition to the routine western medicine. Before and 4 weeks after treatment, the serum hypersensitive C-reactive protein （hs-CRP） was measured. Before and six months after treat- ment, changes of carotid intima-media thickness （IMT） and carotid plaque were examined with Color Doppler Ultrasonography. Results Four weeks after treatment, the hs-CRP level in the treatment group was significantly lowered than before treatment, and the effect was more significant than＇that of the control group （P〈0.01）. Six months after treatment, the IMT of the carotid of both sides was significantly lowered and the size of carotid plaque became significantly smaller, showing a significant difference from before treatment and the control group （P〈0.01）. Conclusion Naoxintong Capsule is effective in lowering the level of hs-CRP, improving the status of carotid intima, and stabilizing the carotid plaque, which is possibly one of the functional mechanisms in the treatment of ACS patients.