摘要
转录因子高度依赖共激活分子从转录水平调控运动诱导生理性适应过程。骨骼肌线粒体核染色体的交互作用取决于转录因子(NRF-1、NRF-2、PPARa、ERRa、Sp1等)和PGC-1家族成员(PGC-1a、PGC-1β和PRC)的相关影响。这些分子组成非常复杂的信号网络,广泛参与耐力训练诱导的线粒体的生物合成。但是这些蛋白对生成新的线粒体的确切的贡献很难进行区分。这些转录因子的目标基因大部分涉及到线粒体的生物合成和细胞的新陈代谢,其转录调控方式可能为了解运动性能量变化特征的信号通路与线粒体生物合成及其功能之间的关系提供基本框架。
Transcription factors are highly dependent on coactivator molecules to affect transcriptional control of training physiologic adaptation processes. Nucleomitochondrial interactions depend on the interplay between transcription factors (NRF-1,NRF-2,PPARa,ERRa,Sp1,and others) and members of the PGC-1 family of regulated coactivators (PGC-1a,PGC-1β,and PRC). These factors participate in a complex network involved in mitochondrial biogenesis in endurance exercise training. However,the exact contribution of each of these proteins to the generation of new mitochondria is rather difficult to dissect. The majority of transcription factors target genes are involved in mitochondrial biogenesis and metabolism. These transcriptional paradigms may provide a basic framework for understanding the integration of mitochondrial biogenesis and function with signaling events that exercise induced energetic properties.
出处
《四川体育科学》
2010年第1期17-20,共4页
Sichuan Sports Science
关键词
转录因子
运动
线粒体
生物合成
Transcription factors
Exercise
Mitochondrial
Biogenesis