白念珠菌分泌型天冬氨酸蛋白酶的研究进展

Aspartyl Proteinases Secreted by Candida albicans

白念珠菌为现代医学最重要的机会性致病酵母菌,严重威胁着患者的生命。分泌型天冬氨酸蛋白酶是白念珠菌分泌的一种酸性蛋白酶家族,与白念珠菌毒力密切相关,由于它至少含有10个成员,各成员之间多方面的差异和错综复杂的关系给科研工作者明确白念珠菌蛋白酶的致病机制带来了困难。近年来,大量研究证实了分泌型天冬氨酸蛋白酶各成员对温度、pH值等培养方面有不同的要求,基因突变技术的发展,进一步明确了基因表达调控与机体感染部位、感染状态之间的关系及转录活化因子在蛋白酶各成员表达中的作用。

Candida albicans is the most important opportunistic pathogenic yeast in modern medicine,threat seriouly to human safety.Secreted aspartyl proteinase is a family of acid proteinase,which is one of the important virulence factors of Candida albicans.Because it is containing at least ten members,many aspects of differences and complex relation in the each member bring difficulty to researcher to further determine pathogenic mechanism of candida albicans.Recently,numerous studies proved that each member of secreted aspartyl proteinase have different requirements in temperature and pH,with develop of gene mutation technology further cleared relation between gene expression regulation and organism′s infection sites and state,as well as transcription activation factor effect on expression of each member of secreted aspartyl proteinase.