T-cadherin与肿瘤

T-cadherin and Tumors

T-cadherin主要介导同种细胞间的黏附和迁移。肿瘤细胞之间通过T-cadherin的作用而发生黏附,不易脱落。近年来大量研究发现,T-cadherin在多种人类肿瘤中表达减少,导致肿瘤细胞间黏附力减弱,从而易引起肿瘤转移。研究者将T-cadherin基因导入缺失表达T-cadherin分子的大鼠胶质母细胞瘤C6细胞,发现C6细胞的增殖及侵袭能力显著受抑,揭示其抑制机制是T-cadherin分子通过诱导p21CIP1/WAF1表达致使肿瘤细胞于细胞周期G2期阻滞,进一步证实DNA启动子区域的甲基化是肿瘤抑制基因失活的主要机制。

T-cadherin mainly mediated by the same kinds of cell-cell adhesion and migration.Between the tumor cells through the role of T-cadherin adhesion took place,not easy to come off.In recent years,large number of studies found that T-cadherin expression in a variety of human tumors to reduce tumor cell adhesion leading to weakened,and thus easy to cause tumor metastasis.Researchers into the T-cadherin gene expression in T-cadherin molecules absence of rat C6 glioblastoma cells and found that the proliferation and invasion of C6 cells significantly inhibited the ability to reveal the inhibitory mechanism of T-cadherin molecules by inducing p21^CIP1/WAF1 expression in tumor cells resulting in cell cycle G2 phase arrest,and further confirmed that DNA methylation of the promoter region of tumor suppressor gene inactivation was the main mechanism.