离子通道改变与癫痫

Ion Channel Change and Epilepsy

癫痫发病机制是大脑神经元放电的异常同步化。正常脑细胞的离子电活动具有一定规律性,神经细胞电位的改变是神经细胞活动和细胞之间信号传递的基础,当神经细胞、神经突触、神经递质、离子通道等改变时,可造成细胞群内外正负电荷的异常流动同步化,癫痫性放电的发作、传播和终止,与遗传、生化、电解质、免疫和微量元素等多种因素有关,不管是何种原因引起,其电生理改变是一致的。

Pathogenesis of epilepsy is the abnormally synchronized discharge of cerebral neural cells.Electrical activities of ions in normal brain cells are usually regular.The change in electrical potential of neural cells is essential for the action and signal transmission of the neural cells.If the abnormalities occur in neural cells,neural synapses,neurotransmitters and ion channels,the electric charge flow of the cell population will synchronize abnormally.The outbreak,transmission and termination of epileptic discharges are associated with genetic,biochemical,electrolytic,immunological and trace element factors.The electrophysiological changes remain constant in epilepsy from any cause.