硝苯地平缓释片与硝苯地平控释片治疗原发性高血压的疗效比较

Antihypertensive Effects of Nifedipine GITS and Nifedipine SR on Patients with Essential Hypertension

目的探讨硝苯地平缓释剂(SR)与硝苯地平控释剂(GITS)治疗原发性高血压的疗效。方法选择132例原发性高血压2级患者,将其随机分为硝苯地平SR组(A组,66例)和硝苯地平GITS组(B组,66例)。A组患者口服硝苯地平SR(伲福达)10mg/次,2次/d;B组患者口服硝苯地平GITS(拜新同)30mg/次,1次/d。6周后进行动态血压监测(ABPM),比较两组患者治疗前后的血压及24h平均血压情况。并观察两组的不良反应情况。结果治疗前两组患者血压间差异无统计学意义(P>0.05);治疗后B组患者收缩压、舒张压及24h平均收缩压、平均舒张压与A组比较,差异均有统计学意义(P<0.05);且两组患者治疗后上述指标与治疗前比较,差异亦有统计学意义(P<0.01);两组不良反应发生情况无明显差异(P>0.05)。结论硝苯地平SR及硝苯地平GITS均能有效降低血压,但后者降压作用更高效、平稳、安全。

Objective To observe the antihypertensive efficacy and influence on biochemistry index of Nifedipine sustained release（SR）and Nifedipine gastro-intestinal therapeutic system（GITS）.Methods The subjects in this study consisted of 132 hypertensive patients（grade 2）.The 132 hypertensive patients were averagely divided to two groups：Nifedipinc SR group （A group,66 cases）and Nifedipine GITS group（B group,66 cases）.The patients of A group were treated with Nifedipinc SR,PO,tid,10mg every time,The patients of B group were treated with Nifedipine GITS,PO,qd,30mg every time.ABPM were done after 6 weeks,and the blood pressure and the 24h average blood pressure were compared between the two groups before and after treatment.And the untoward reaction in two groups patients were observed.Results Blood pressure before treatment between the two groups no statistically significant difference（P〈0.05）; group B after treatment in patients with systolic and diastolic blood pressure,and 24 h average systolic and mean diastolic blood pressure compared with the A group,the differences were statistically significant（P〈0.05）; and the two groups after treatment compared with those before treatment the above-mentioned indicators,differences were also statistically significant（P〈0.01）.And the untoward reaction rates had no difference between two groups.Conclusion Nifedipine SR and nifedipine GITS can effectively lower blood pressure,antihypertensive effect,but the latter is more efficient,stable and safe.