摘要
目的:观察连芪消渴胶囊对2型糖尿病大鼠的治疗作用。方法:高糖高脂饲料喂养4周后,ip 30 mg.kg-1链脲佐菌素制备2型糖尿病大鼠模型,分组并给药治疗8周,取血检测空腹血糖、胰岛素、总胆固醇、甘油三酯、超氧化物歧化酶、丙二醛,计算胰岛素敏感指数及光镜下观察胰腺病理组织学变化。结果:模型组与正常对照组比较:血糖、总胆固醇、甘油三酯、丙二醛水平明显升高(P<0.05,P<0.01),胰岛素、胰岛素敏感指数、超氧化物歧化酶明显降低(P<0.05),胰岛细胞损伤明显;连芪消渴胶囊治疗组与模型组比较:血糖、总胆固醇、甘油三酯、丙二醛水平明显降低(P<0.05,P<0.01),胰岛素、胰岛素敏感指数、超氧化物歧化酶明显升高(P<0.05),胰岛细胞损伤减轻。结论:连芪消渴胶囊具有降低大鼠空腹血糖和血脂的作用,其机理可能与提高胰岛素敏感性、修复损伤的胰岛细胞和改善体内氧化应激水平有关。
Objective:To research the effect of Lianqi Xiaoke Capsule on type 2 diabetic rats.Method: Type 2 diabetic rat model wase induced with high sucrose-fat diet for 4 weeks and streptozotocin ip for 30 mg.kg-1,all animals were grouped and administrated with drugs for 8 weeks.The fasting blood glucose,insulin,insulin sensitivity index,total cholesterol,triglyceride,superoxide dismutase and malondialdehyde were assessed and pancreatic pathological changes were observed.Result: ① model group vs normal control group: the fasting blood glucose,total cholesterol,triglyceride,malondialdehyde were obviously increased(P 0.05,P 0.01),otherwise insulin,insulin sensitivity index,superoxide dismutase decreased(P 0.05),pancreatic damage were appeared;② Lianqi Xiaoke Capsule treatment groups vs.model group: the fasting blood glucose,total cholesterol,triglyceride,malondialdehyde were significantly decreased(P 0.05,P 0.01),and insulin,insulin sensitivity index,superoxide dismutase increased(P 0.05),pancreatic damage were ameliorated.Conclusion: Lianqi Xiaoke Capsule could decrease fasting blood glucose and blood lipids via ameliorating pancreatic damage and insulin resistance,and inhibition of oxidative stress.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第4期131-134,共4页
Chinese Journal of Experimental Traditional Medical Formulae