连芪消渴胶囊对2型糖尿病大鼠治疗作用的实验研究

Experimental study of effect of Lianqi Xiaoke Capsule in type 2 diabetic rats

目的:观察连芪消渴胶囊对2型糖尿病大鼠的治疗作用。方法:高糖高脂饲料喂养4周后,ip 30 mg.kg-1链脲佐菌素制备2型糖尿病大鼠模型,分组并给药治疗8周,取血检测空腹血糖、胰岛素、总胆固醇、甘油三酯、超氧化物歧化酶、丙二醛,计算胰岛素敏感指数及光镜下观察胰腺病理组织学变化。结果:模型组与正常对照组比较:血糖、总胆固醇、甘油三酯、丙二醛水平明显升高(P<0.05,P<0.01),胰岛素、胰岛素敏感指数、超氧化物歧化酶明显降低(P<0.05),胰岛细胞损伤明显;连芪消渴胶囊治疗组与模型组比较:血糖、总胆固醇、甘油三酯、丙二醛水平明显降低(P<0.05,P<0.01),胰岛素、胰岛素敏感指数、超氧化物歧化酶明显升高(P<0.05),胰岛细胞损伤减轻。结论:连芪消渴胶囊具有降低大鼠空腹血糖和血脂的作用,其机理可能与提高胰岛素敏感性、修复损伤的胰岛细胞和改善体内氧化应激水平有关。

Objective：To research the effect of Lianqi Xiaoke Capsule on type 2 diabetic rats.Method： Type 2 diabetic rat model wase induced with high sucrose-fat diet for 4 weeks and streptozotocin ip for 30 mg.kg-1,all animals were grouped and administrated with drugs for 8 weeks.The fasting blood glucose,insulin,insulin sensitivity index,total cholesterol,triglyceride,superoxide dismutase and malondialdehyde were assessed and pancreatic pathological changes were observed.Result： ① model group vs normal control group： the fasting blood glucose,total cholesterol,triglyceride,malondialdehyde were obviously increased（P 0.05,P 0.01）,otherwise insulin,insulin sensitivity index,superoxide dismutase decreased（P 0.05）,pancreatic damage were appeared;② Lianqi Xiaoke Capsule treatment groups vs.model group： the fasting blood glucose,total cholesterol,triglyceride,malondialdehyde were significantly decreased（P 0.05,P 0.01）,and insulin,insulin sensitivity index,superoxide dismutase increased（P 0.05）,pancreatic damage were ameliorated.Conclusion： Lianqi Xiaoke Capsule could decrease fasting blood glucose and blood lipids via ameliorating pancreatic damage and insulin resistance,and inhibition of oxidative stress.