花川保列颗粒对大鼠非菌性前列腺炎模型的实验研究

Experimental study of Huachuanbaolie Granules on nonbacterial prostatitis in rats

目的:观察花川保列颗粒对大鼠急、慢性非细菌性前列腺炎症模型的影响及其对一般炎症与疼痛模型的作用。方法:在大鼠前列腺内注入角叉菜胶,造成非细菌性急性前列腺炎和慢性前列腺炎,观察花川保列颗粒对前列腺液中白细胞数、卵磷脂小体密度及腺体组织学改变的影响。采用二甲苯致小鼠耳肿胀模型和大鼠棉球肉芽肿模型观察其抗炎作用,采用醋酸扭体模型观察其镇痛作用。结果:大鼠灌胃给予花川保列颗粒可减少角叉菜胶所致急性前列腺炎模型大鼠的前列腺液中的白细胞数和卵磷脂小体,改善慢性模型大鼠前列腺的病理变化;抑制二甲苯引起的小鼠耳肿胀;减轻大鼠棉球肉芽肿重量。对醋酸引起的扭体反应有明显抑制作用。结论:花川保列颗粒对大鼠实验性非菌性前列腺炎具有治疗作用。

Aim： To investigate the effects of Huachuanbaolie Granules（HCBL） on nonbacterial prostatitis and its anti-inflammatory and analgesia activity.Methods： Acute and chronic nonbacterial prostatitis model in rats were induced by carrageenin,Effects of HCBL on count of white blood cells,density of lecithin corpuscle in secretion and histological changes of prostates were observed.The anti-inflammatory activity was evaluated by xylene-induced ear edema in mice and cotton pellet-induced granuloma in rats.Analgesia activity was tested according to acetic acid-induced writhing in mice.Results： HCBL lowered the count of white blood cells,increased the density of lecithin corpuscle in secretion of prostates,and inhibited inflammatory infiltration,edema and fibroblast proliferation in carrageenin-induced acute or chronic prostatitic rats.Anti-inflammatory activity was confirmed in cotton pellet-induced granuloma in rat.HCBL could obviously decrease the writhing number induced by acetic acid and inhibit the ear edema induced by xylene in mice.Conclusion： The data suggest that HCBL has anti-inflammation and analgesia effects,It is an effective medicine for the treatment of prostatitis.