(S)-(+)-γ-苄氧基甲基-γ-丁内酯的合成研究

Study on the Synthesis of (S) (+) γ Benzyloxymethyl γ butyrolactone

以Ｌ谷氨酸为原料，首先在－５～０℃条件下重氮化，随后常温内酯化，然后在对甲苯磺酸催化下于苯中回流进行酯化，用硼氢化钠在常温下还原，最后用氧化银作为碱发生常温威廉逊（Ｗｉｌｉａｍｓｏｎ）醚化反应，以３２３％的总产率合成了标题化合物。

Through diazotisation in the condition of -5～0℃ (followed by lactonization at room temperature),esterification in the refluxing benzene using TsOH as catalyst,reduction by NaBH 4 at room temperature and Williamson etherification at room temperature using Ag 2O as base,the title compound was synthesized in the total yield of 32.3% from L glutamic acid as starting material.