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脑血管畸形患者VEGF的表达及临床意义 被引量：2

The Expression of VEGF in Cerebral Vascular Malformation and Its Significance
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摘要 目的观察脑血管畸形(CVM)患者血管内皮生长因子(VEGF)蛋白的表达情况,探讨VEGF蛋白在脑血管畸形患者中的表达特点与意义。方法应用免疫组织化学方法检测62例脑血管畸形患者标本中VEGF蛋白的表达。结果 62例脑血管畸形标本中,VEGF蛋白在畸形血管中阳性表达率为72.6%(45/62),畸形血管周围正常脑组织中血管的VEGF蛋白阳性表达率为51.6%(32/62),两者比较有差异(P<0.05)。结论 VEGF参与CVM的发生发展。 Objective To investigate the expression of VEGF in Cerebral Vascular Malformation（CVM）and find out its significance. Methods The expression of VEGF were assessed by immunohistochemistry staining. Results In 62 cease of CVM positive expression rates of VEGF was 72.6% （45/65）and 51.6% （32/62）in normal brain tissues. The positive rate was higher in CVM than in normal brain tissues （P〈 0.05）. Conclusion VEGF might take part in the pathogenesis of cerebral CVM development and growth.
作者 杨延莉 魏茂富 刘镜文
机构地区 东莞市虎门医院内三科 东莞市虎门医院病理科
出处 《中国现代医生》 2010年第11期156-157,共2页 China Modern Doctor
关键词 血管内皮生长因子 脑血管畸形 免疫组化 VEGF CVM Immunohistochemistry
分类号 R743.4 [医药卫生—神经病学与精神病学]
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参考文献7

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同被引文献13

  • 1胡锦,龚佳蕾,徐涛,姚海军,栗超跃,赵曜,周良辅.血管形成因素在颅内海绵状血管瘤中的表达[J].中国基层医药,2005,12(7):771-773. 被引量：4
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中国现代医生
2010年 第11期

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