实验犬放置镍钛合金气道Y形支架的基础研究

The placement of Y-shaped titanium-nickel memory alloy stent in the carina:a fundamental study in experimental canines

目的观察气道Y形镍钛合金支架放置后气道局部病理改变,并探讨CT三维重建技术在支架放置术后评价及随访中的应用价值。方法健康成年家犬12只,根据CT气道三维重建技术测量所得隆突部位数据研制模具,并由单支镍钛合金丝编织Y形气道支架,利用支架释放系统将支架置入家犬气道隆突部位。术后CT随访气道三维重建和纤维支气管镜检查。放置12周后处死动物取出支架段气管行病理学检查。结果支架成功地置入动物气道隆突部位,术后12周检查气道通畅,病理学检查支架已出现上皮化。结论①Y形镍钛合金气道支架释放便利,组织相容性好,3个月时未见气道再狭窄及排痰困难。②CT三维成像技术作为一种无创、方便的检查方法对于气道支架放置及术后随访有很好的应用价值。

Objective To investigate the pathological changes of local airway tissue after inserting Yshaped titanium-nickel memory alloy stent in carina, and to evaluate CT three-dimensional reconstruction technique in postoperative and follow-up observation.Methods Twelve healthy adult canines were enrolled in this study.Based on the information of the carina obtained from CT three-dimensional reconstruction images, the preparation of Y-shape netlike stent was made by knitting method with single Ni-Ti memory alloy wire.The stent was then inserted in canine＇s carina with the help of a releasing system.After the operation fiberbronchoscopy and CT three-dimensional reconstruction were performed.The animals were sacrificed 12 weeks after the procedure and the bronchus of the stenting segment was removed and sent for histopathologic examination.Results Technical success was achieved in all canines with the stent right in the carina.The airway remained unobstructed 12 weeks after the procedure.Histopathologic examination revealed that the stent became partial epithelialization.Conclusion The Y-shaped titanium-nickel memory alloy stent has good histocompatibility and physicochemical stability and no re-stenosis of the airway develops in the follow-up period of three months.The stent-releasing technique is easy and simple.As a non-invasive and convenient exam, CT three-dimensional reconstruction technique is of great value in postoperative follow-up observation.