胎羊脐带血管和肝内静脉超声引导穿刺取血的对比观察

Comparison of cordocentesis and intrahepatic umbilical vein sampling with ultrasonographic guidance in the ovine fetus

目的观察、比较胎羊脐带穿刺术(CC)取血和肝内脐静脉穿刺术(IUVS)取血的成功率和并发症发生率。方法晚孕胎羊20只,随机分为CC组和IUVS组,于超声引导下进行CC和IUVS,计算其穿刺取血的成功率和并发症发生率。结果IUVS取血1次、3次以内和5次以内成功率分别为32.00%、68.00%和84.00%,明显优于CC组成功率(分别为15.00%、40.00%和75.00%,P<0.05),而并发症发生率两者相当(P>0.05)。结论IUVS是可供选择的较为理想和方便的孕胎血管的介入路径。

Objective To compare success and complication rate of cordocentesis（CC） with intrahepatic umbilical vein sampling（IUVS） under the guidance of ultrasonography in ovine fetus.Methods Twenty near-term singleton pregnant ewes were randomly divided into CC group and IUVS group（each n= 10）.All of the ewes underwent CC or IUVS in ovine fetus guided with ultrasonography.Success and complication rate of CC and IUVS were calculated.Results Success rates of IUVS on the first,less than 3 times and 5 times attempt was 32.00%,68.00% and 84.00%,respectively,higher than that of CC（15.00%,40.00% and 75.00%,respectively,P 0.05）.Sever complication rates of IUVS in comparison with CC was not statistically different（P 0.05）.Conclusion Fetal IUVS may be a reasonable option to obtain fetal intravascular access and facilitate therapeutic intervention.