新型可回收下腔静脉滤器的体外实验研究

Evaluation of a newly designed retrievable inferior vena cava filter in vitro flow model

目的通过建立体外模型,评估新型可回收下腔静脉滤器的滤过效果及稳定性。方法在体外建立下腔静脉模型,在不同管径、不同大小栓子及不同位置上分别评价滤器的稳定性及对栓子的捕获能力,并与Recovery可回收滤器进行对比。用牛血管重复实验,观察新型滤器滤过效果及稳定性。结果在体外下腔静脉模型中,新型可回收滤器对直径为2、3、5 mm的栓子滤过率分别为91.50%、96.50%和99.50%,管径为21、28 mm时滤过率为别为98.00%、93.67%,水平及垂直条件下栓子滤过率为94.33%、97.33%,总体滤过率为95.83%。Recovery可回收滤器在以上条件下的滤过率分别为81.00%,91.00%,95.00%;92.33%,85.67%及87.67%,90.33%,总体滤过率为89.00%。用牛血管取代硅胶管后,新型滤器在不同条件下的滤过率分别为88.50%,94.00%,98.00%;94.67%,92.33%及91.33%,95.67%,总体滤过率为93.50%。在实验过程中,两种滤器均未发现明显移位及偏斜现象。结论新型可回收下腔静脉滤器滤过效果及稳定性可靠,体外实验滤过效果优于Recovery滤器。

Objective To evaluate the efficacy and stability of a newly designed retrievable inferior vena cava（IVC） filter in vitro experiment.Methods In the flow model,thrombus capture rate and stability of the new IVC filter,and the Recovery retrievable filter were tested in varied thrombus size,tube diameters and positions.The process was repeated with a piece of cow aorta to observe the capture rate and stability.Results The emboli capture rate of different embolism diameter（2,3,5 mm） was 91.50%,96.50% and 99.50%,respectively.For two tube diameter（21,28 mm） was 98.00% and 93.67%,respectively.For the two directions（horizontal,vertical） was 94.33%,97.33%,and the total capture rate was 95.83%.Under those different conditions,the capture rates of Recovery filter was 81.00%,91.00%,95.00%;92.33%,85.67% and 87.67%,90.33%,respectively,while the total capture rate was 89.00%.Using the cow vessel,the capture rate was 88.50%,94.00%,98.00%;94.67%,92.33%;91.33%,95.67%,respectively;and the total rate was 93.50%.During experiment,two types of filter did not move or deflect.Conclusion The newly designed retrievable IVC filter is effective and stable in vitro study,and the capability of trapping emboli is better than that of Recovery filter.