离子通道对皮肤屏障修复的影响

Influences of ion channels on skin barrier repair

皮肤的屏障功能需不断更新和修复来维持，离子通道通过调控角质形成细胞胞内外离子浓度的变化来影响屏障修复的速度。相关的离子通道有电压门控性钙离子通道、电压门控性钾离子通道、电压门控性钠离子通道、配体门控性氯离子通道和配体门控性非选择性阳离子通道（包括P2X受体、TRPV离子通道、谷氨酸离子通道和烟碱型乙酰胆碱受体）。离子通道可直接介导信号转导，也可通过神经递质由G蛋白耦联受体介导信号转导来影响屏障修复。

The barrier function of epidermis is maintained via continuous renewal and repair. Ion channels can influence the speed of barrier repair via modulating intracellular and extracellular ion concentration of keratinocytes. Related ion channels include voltage-gated calcium channel, voltage-gated magnesium channel, voltage-gated sodium channel, ligand-gated chloride channel, and ligand-gated non-selective cation channel. P2X receptor, TRPV receptor, glutamate receptor and nicotinic acetylcholine receptor all belong to ligand-gated non-selective cation channel Ion channels affect barrier repair by either direct or indirect mediation of signal transduction via neurotransmitters and G protein-coupled receptors.