银屑病分子遗传学研究进展

Molecular genetics of psoriasis

银屑病是一种由环境因素和遗传因素共同作用的多因素的复杂疾病。既往研究多采取家系连锁分析、候选基因的方法，但其检测效能较低。目前基于第三代遗传标记的单核苷酸多态性寻找疾病易感基因的全基因组关联分析在复杂疾病的广泛应用，使得银屑病的遗传学发病基础研究进入新阶段，并可能为银屑病提供新的治疗靶点。

Psoriasis is recognized as a complex multifactorial disease affected by environmental and genetic factors. Familial linkage analysis and candidate gene-based methods, which were commonly used in previous studies have limited detection sensitivity. Recently, the application of genome-wide association studies based on single nucleotide polymorphisms has promoted the exploration in genetic basis of psoriasis, and might offer new treatment targets for psoriasis.