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胸腺基质淋巴细胞生成素在皮肤黏膜免疫中的作用 被引量：1

Thymic stromal lymphopoietin in mucocutaneous immunity
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摘要 胸腺基质淋巴细胞生成素是近期发现的一种细胞因子，结构和功能类似于IL-7，通过胸腺基质淋巴细胞生成素受体发挥生物学作用。胸腺基质淋巴细胞生成素可由皮肤角质形成细胞、黏膜上皮细胞、嗜碱粒细胞、肥大细胞及平滑肌细胞产生，主要参与淋巴细胞生长、T细胞分化及过敏性炎症的发生，在皮肤黏膜天然免疫中起重要作用。目前发现，胸腺基质淋巴细胞生成素在特应性皮炎、白癜风、皮肤T淋巴细胞瘤、哮喘及过敏性鼻炎等疾病的发生中起重要作用。 Thymie stromal lymphopoietin （TSLP） is a newly discovered IL-7-like cytokine that plays biological effects via activating its receptor. TSLP can be secreted by skin keratinocytes, mueosal epithelium, basophils, mast cells and smooth muscle cells. It plays an essential role in the innate immunity of skin and mucosa because of its participation in lymphocyte development, T cell differentiation and development of allergie inflammation. Recent studies have demonstrated that TSLP plays an important role in the pathogenesis of atopic dermatitis, vitiligo, cutaneous T cell lymphoma, asthma, allergic rhinitis, etc.
作者 高涛 陈嵘祎 樊翌明
机构地区 广东医学院附属医院皮肤科
出处 《国际皮肤性病学杂志》 2010年第2期110-112,共3页 International Journal of Dermatology and Venereology
关键词 胸腺基质淋巴细胞生成素 黏膜 细胞因子类 Thymie stromal lymphopoietin Mucous membrane Cytokines
分类号 R392 [医药卫生—免疫学]
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参考文献20

  • 1Metz M,Maurer M.Innate immunity and allergy in the skin.Curr Opin Immunol,2009,[Epub ahead of print].
  • 2Soumelis V,Reche PA,Kanzler H,et al.Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.Nat Immunol,2002,3(7):673-680.
  • 3Mou Z,Xia J,Tan Y,et al.Overexpression of thymic stromal lymphopoietin in allergic thinitis.Acta Otolaryngol,2009,129(3):297-301.
  • 4Allakhverdi Z,Comeau MR,Jessup HK,et al.Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes.trauma,or inflammation and potendy activates mast cells.J Exp Med.2007,204(2):253-258.
  • 5Cheong KA,Chae SC,Kim YS,et al.Association of thymic stromal Iymphopoietin gene -847C 》T polymorphism in generalized vitiligo.Exp Dermatol,2009,18 (12):1073-1075.
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  • 8Liu YJ,Soumelis V,Watanabe N,et al.TSLP:an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.Annu Rev Immunol,2007,25:193-219.
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同被引文献9

  • 1Omori M, Ziegler S. Induction of IL-4 expression in CD4 (+) T cells by thymic stromal lymphopoietin[J]. J lmmunol, 2007, 178(3): 1396-1404.
  • 2Reche P A, Soumelis V, Gorman D M, et al. Human thymie stromal lymphopoietin preferentially stimulates myeloid cells[J]. J Immunol, 2001, 167(1): 336-343.
  • 3Rimoldi M, Chieppa M, Salucei V, et al. Intestinal immune homeostasis is regulated by the erosstalk between epithelial cells and dendritic cells[J]. Nat Immunol, 2005, 6(5): 507- 514.
  • 4A1-Shami A, Spolski R, Kelly J, et al. A role for TSLP in the development of inflammation in an asthma model[J]. J Exp Med, 2005, 202(6): 829-839.
  • 5Liu Y J. Thymic stromal lymphopoietin: master switch for allergic inflammation[J]. J Exp Med, 2006, 203(2): 269-273.
  • 6Watanabe N, Hanabuchi S, Soumelis V, et al. Human thymie stromal lymphopoietin promotes dendritic cell-mediated CD4 + T cell homeostatic expansion[J]. Nat Immunol, 2004, 5(6): 426-434.
  • 7Artis D. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut[J]. Nat Roy Immunol, 2008, 8(6): 411-420.
  • 8Lee H C, Zicglcr S E Inducible expression of the proallcrgic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NF K B[J]. Proc Natl Acad Sci USA, 2007, 104(3): 914-949.
  • 9陈嵘祎,樊翌明,高涛,杨艳平,张国学.小鼠念珠菌性阴道炎模型中TSLP表达及其与IL-2,IL-10关系[J].中国皮肤性病学杂志,2010,24(6):509-511. 被引量：13

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国际皮肤性病学杂志
2010年 第2期

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