摘要
MicroRNA(miRNA)是一类新发现的、非编码的、大小约为22个核苷酸,参与转录后基因调控的RNA,广泛存在于动植物中.研究已经证实,miRNA在细胞的增殖、凋亡、分化、个体发育等方面发挥着巨大作用,另外miRNA与肿瘤的发生和发展密切相关,发挥着癌基因或抑癌基因的作用.本文主要介绍miRNA的产生、作用机制、生物功能以及在胆管癌的发生和发展中的作用.
MicroRNAs （miRNAs） are a class of short non-coding RNAs widely distributed in plants and animals. They can inhibit the expression of protein-coding genes by binding to the 3＇ UTR of mRNAs and inducing either translational repression or mRNA degradation. It has been demonstrated that miRNAs play important roles in regulating cell proliferation, apoptosis and differentiation. In addition, miRNAs can function as oncogenes or tumor suppressor genes and are therefore closely associated with oncogenesis. This review will focus on the biogenesis, silencing mechanism, and biological function of miRNAs, and their roles in the development and progression of cholangiocarcinoma.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第6期563-567,共5页
World Chinese Journal of Digestology
基金
福建省自然科学基金资助项目
No.2009D014~~
