静脉滴注联合鞘内注射头孢他啶治疗脑室出血穿刺引流术后颅内感染94例疗效观察

Treatment for 94 Cases Intracranial Infection after Lateral Ventricle Puncture Using Intravenous Infusion Combined with Intrathecal Injection of Ceftazidime

目的:探讨静脉滴注联合鞘内注射头孢他啶对脑室出血穿刺引流术后颅内感染的治疗作用。方法:自2002年至2009年,选取脑室出血穿刺引流术后发生颅内感染的病人共94例。分两组(每组47例),第一组病人采用单纯静脉滴注头孢他啶治疗,第二组病人采用静脉滴注联合鞘内注射头孢他啶治疗。观察两种方法的疗效差异。结果:单纯静滴头孢他啶治疗38例病人治愈,9例未愈;静滴联合鞘注头孢他啶治疗44例病人治愈,3例未愈,治愈病人数明显多于单纯静滴组,两组差别有显著意义(P<0.01)。结论:静脉滴注联合鞘内注射头孢他啶能显著提高脑室出血穿刺引流术后颅内感染病人的疗效。

Objective： To investigate the therapeutic effect to intracranial infection after lateral ventricle puncture using intravenous infusion combined with intrathecal injection of ceftazidime.Method： From 2002 to 2009,we treated a total of 94 intraventricular hemorrhage patients with intracranial infection after lateral ventricle puncture,the cases were divided into two groups（n = 47 cases）,the first group accepted intrathecal injection of ceftazidime alone,the second group were treated with intravenous infusion combined with intrathecal injection of ceftazidime.And then evaluate the differences in the efficacy of two methods.Result：38 patients were cured in the first group which accept intravenous infusion of ceftazidime alone;however,the cured cases in the second group were 44,which is much more than that in the first group,the difference was significant（P 0.01）.Conclusion： Intravenous infusion combined with intrathecal injection of ceftazidime can significantly increase the efficacy of intracranial infection after lateral ventricle puncture in intraventricular hemorrhage patients.