进展性与非进展性缺血性脑卒中患者血清NO水平变化的对比研究

Contrastive study on changes of nitric oxide level in serum of patients with progressive and non-progressive ischemic stroke

目的研究进展性与非进展性缺血性脑卒中患者血清NO水平变化,为进展性缺血性脑卒中的预测及治疗提供科学的依据。方法采用比色法分别对进展性与非进展性缺血性脑卒中患者(各30例)及对照组不同相应时间点的血清进行NO水平检测,并对结果进行比较。结果进展组的NO水平顺序依次为,进展后24h内>1d及7d>14d;在发病1w内,进展组NO水平均明显高于非进展组,而在发病2w左右,两者逐渐接近正常水平。结论血清NO水平升高可作为进展性缺血性脑卒中的预测指标。

Objective To provide a scientific basis to prediction of progressive ischemic stroke through contrastive study on changes of nitric oxide level in serum of patients with progressive or non-progressive ischemic stroke and the control group. Methods Nitric oxide level at different corresponding time points in serum of above-mentioned three groups of patients was detected by colorimetry method,and the results were compared. Results The order of nitric oxide level in progressive ischemic stroke group was that within 24h after deterioration（1d and 7d after the onset）14d after the onset. Nitric oxide level in progressive ischemic stroke group was significantly higher than non-progressive ischemic stroke group during 1w after the onset,while they gradually returned to nearly normal level at about 2w after the onset. Conclusion Elevated nitric oxide level in serum could be a prediction index of progressive ischemic stroke.