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多灶性运动神经病5例分析及文献回顾 被引量:1

Analyzing of 5 Multifocal motor neuropathy cases and literature reviewing
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摘要 目的探讨多灶性运动神经病(MMN)的临床和电生理特点及诊断标准。方法分析我院收治的5例MMN患者的临床表现,电生理改变,实验室检查结果及治疗情况,并结合相关文献报道综合分析。结果5例病例均为男性患者,发病年龄在28~42岁,均以单肢无力为首发症状,远端重于近端;3例伴有肌肉萎缩;5例均无感觉障碍,腱反射减低,无病理反射;肌电图及神经传导速度检查提示神经源性损害,无巨大电位,3例出现了典型的运动神经多发传导阻滞(CB);4例经免疫球蛋白治疗后有不同程度好转。结论MMN的诊断应注意与慢性格林巴利(CIDP)及运动神经元病(MND)相鉴别,结合临床及电生理特点综合分析,以免误诊。 Objective To approach the clinical and electrophysiological features and diagnostic criteria of multifocal motor neuropathy(MMN). Methods Analyzed the clinical situation,electrophysiological changes,laboratory examination result and the treatment state of the 5 patients of MMN who were treated in our hospital,and analyzed comprehensively by combining with relevant literature. Results All of the 5 cases were male patients,the age range from 28 to 42 years old,and the first symptom was weak in single-limb,the distal was more serious than the dorsal;3 patients had muscular dystrophy;5 patients had no sensory disability,no reducing in the tendon reflex and pathological reflex;EMG and nerve conduction velocity inspection prompted that it was neurogenic damage without great potential,there was typical multiple conduction block(CB)in 3 cases;4 patients got better in varying degrees after treated with immune globulin. Conclusion The diagnosis of MMN should be noted to identify with the chronic Guillain-Barre(CIDP)and motor neuron disease(MND),we should differentiate analyze comprehensively by combinating together with clinical and electrophysiological characteristics in order to avoid misdiagnosis.
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2010年第3期248-249,共2页 Journal of Apoplexy and Nervous Diseases
关键词 多灶性运动神经病 诊断 Multifocal motor neuropathy Diagnosis
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参考文献6

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