降脂颗粒联合行为干预治疗痰瘀互结型非酒精性脂肪性肝病的临床研究

Clinical study of "Jiangzhi Granule" and behavioral intervention for nonalcoholic fatty liver disease of phlegm and blood-stasis syndrome

目的评价降脂颗粒联合行为干预治疗痰瘀互结型非酒精性脂肪性肝病的临床疗效。方法采用随机区组设计方法将144例患者分为治疗组和对照组各72例,两组均采用行为干预,治疗组同时口服降脂颗粒(10g/次,3次/d)。两组均连续治疗24周,治疗后评价肝脏散射子定量超声、临床症状的改善情况,并进行综合疗效评价。结果治疗组治疗后肝脏B超显示病情较前改善(P<0.01),与对照组治疗后比较差异有统计学意义(P<0.05);治疗组治疗后症状总积分较治疗前下降(P<0.05),且较对照组治疗后为低(P<0.05);治疗组、对照组总有效率分别为76.56%和52.54%,组间疗效比较差异有统计学意义(P<0.01)。结论降脂颗粒联合行为干预能有效改善患者肝脏脂肪浸润,并缓解临床症状。

Objective To evaluate the curative effect of ＂Jiangzhi Granule＂ and behavioral intervention on nonalcoholic fatty liver disease （NAFLD） of phlegm and blood-stasis syndrome. Methods A randomized block investigation was used to divide 144 patients into two groups on average： treatment group in which 72 patients were given behavioral intervention and ＂Jiangzhi Granule＂, and control group in which 72 patients Were given behavioral intervention alone. Clinical syndromes and amelioration of backscattered quatitative ultrasonography were determined, and total curative effect was envaluated after 24-weeks treatment. Results The hepatic B-ultrasonography showed improvement in the treatment group after treatment （ P 〈 0. 01 ）, with a difference compared with the control group （ P 〈0.05 ） ; the total score of the treatment group decreased after treatment （ P 〈0.05 ）, and was lower than that of the control group after treatment（ P 〈0.05 ）. The total effective rate was 76.56% in the treatment group and 52.54% in the control group（P 〈0.01 ）, with a statistic significance between them（P 〈0.01 ）. Conclusion ＂Jiangzhi Granala＂ plus behavioral intervention can effectively improve fatty infiltration of liver in NAFLD patients, and relieve their symptoms.