血管内皮生长因子受体-1和COX-2在胃癌中的表达及临床意义

Expression and clinical significance of Flt-1 and COX-2 in gastric cancer

目的研究血管内皮生长因子受体-1(Flt-1)和环氧合酶-2(COX-2)在胃癌中的表达及其临床意义。方法选择80例手术切除的胃癌标本为观察组,30例胃癌旁、40例慢性非萎缩性胃炎组织为对照组,应用免疫组织化学方法检测组织中Flt-1及COX-2的蛋白表达。结果Flt-1及COX-2在胃癌中的表达率均为52.5%,在癌旁及对照组的阳性率分别为13.3%、0%、7.5%、0%,差异均有统计学意义(P<0.01),二者的表达与胃癌的TNM分期及浸润呈正相关,它们的阳性表达强度与肿瘤淋巴及血道转移呈正相关(P<0.05),与肿瘤大小、分化程度无关(P>0.05)。Flt-1、COX-2在胃癌组织中表达呈正相关(γ=0.608,P=0.000)。结论Flt-1、COX-2参与胃癌的发生、发展,二者在胃癌的发生、浸润转移中可能存在相互协同作用,联合检测Flt-1、COX-2可作为胃癌浸润、转移的重要判定指标。

Objective To investigate the expression and clinical significance of vascular growth factor reeeptor-1 （Flt-1） and COX-2 in gastric cancer. Methods Tissue section from 80 gastric cancer（GC） ,30 tissue section from side gastric cancer,40 chronic non -atrophy gastritis tissue were examined by using immunohistochemistry for the expression of Flt-1 and COX-2. Results The positivity rates of Flt-1 and COX-2 were both 52.5% ,which were significantly higher than that in patients with side gastric cancer and chronic non -atrophy gastritis tissue（13. 3% .0% .7.5% ,0%, P〈0.01〉. The high positive expression of two indexes had positive correlation with regional invasion and lymphatic and blood stream metastasis in GC, But had no correlation with the size and differentiation degree. There was significant correlation between the expression of Flt-1 and COX-2. Conclusion Flt-1 and COX-2 might be associated with the development of gastric cancer. The two indexes may pay coordination role in anginogenesis,invasion in gastric cancer.