阿尔茨海默症患者MR图像胼胝体和扣带回部位纹理分析

Texture Analysis of Corpus Callosum and Cingulate on Magnetic Resonance Image in Patients with Alzheimer's Disease

目的研究阿尔茨海默病患者与对照组胼胝体和扣带回部位纹理参数的特点,并测试纹理参数和AD(Alzheimer,s diease,阿尔茨海默病)病程进展的相关性。方法采用灰度共生矩阵的纹理分析方法对患者和健康对照组MR图像上胼胝体和扣带回部位提取纹理参数,并比较纹理参数与MMSE(mini-mental state examination,简易精神状态检查)评分的相关性。结果AD患者和对照组胼胝体及扣带回部位的纹理参数存在显著性差异,扣带回部位的纹理参数和MMSE评分显著相关。结论本研究表明纹理分析可以量化描述AD患者胼胝体和扣带回的病理变化,可能为早期诊断提供帮助。

Objective To study the characteristic of the texture features in corpus callosum and cingulate of Alzheimer＇ s disease （AD） and normal control group, and test the relationship between texture features and AD disease progression. Methods Corpus eallosum and eingulate were selected as regions of interests （ROIs）. Texture features were extracted from gray level co-occurrence matrix in ROIs,and the correlation between texture features and MMSE scores were calculated. Results Texture features in corpus callosum and eingutate were significantly different between AD and normal controls group and texture features in eingulate was significantly correlated with MMSE scores. Conclusion The study demonstrated that texture analysis was able to quantify the pathological changes of corpus callosum and cingulate in MR image of AD patients and may aid in early diagnosis of AD.