子宫内膜异位症患者血清基质金属蛋白酶-9及其诱导因子血管内皮生长因子的变化

MMP-9,EMMPRIN and VEGEF in plasma of women with endometriosis

目的探讨细胞外基质金属蛋白酶诱导因子（EMMPRIN）、基质金属蛋白酶-9（MMP-9）、血管内皮生长因子（VEGF）在子宫内膜异位症患者血清中表达水平的变化及其临床意义。方法收集70例子宫内膜异位症（EMs）患者（其中Ⅰ期10例、Ⅱ期14例、Ⅲ期28例、Ⅳ期18例）和20例对照组患者的血清,以及30例EMs患者手术加药物治疗后的血清标本,采用酶联免疫吸附法（ELISA）定量检测血清中EMMPRIN、MMP-9、VEGF的表达水平。结果EMs患者血清中三者的表达水平高于对照组（P〈0.05）,早期患者（Ⅰ~Ⅱ期）血清中三者低于Ⅲ~Ⅳ期（P〈0.05）;手术加药物治疗后EMs患者血清VEGF水平可显著性降低;血清VEGF水平与临床分期呈直线正相关关系（P〈0.05,r=0.396）。结论EMMPRIN、MMP-9、VEGF在EMs发病中起着重要作用,检测血清中VEGF水平对于EMs患者随访监测及评价临床疗效有一定价值。

Objective To study the significance of detection of EMMPRIN,MMP-9 and VEGF in plasma of women with endometriosis.Methods We measured the concentrations of EMMPRIN,MMP-9 and VEGF in plasma of women with endometriosis（n=70） and compared them with those in a control group（n=20）,as assessed by enzyme-linked immunosorbent assay（ELISA）.Results The concentrations of MMPRIN,MMP-9 and VEGF in the plasma of patients with endometriosis was higher than that in the control group（P 0.05）.The same result appeared in advanced stage compared with early stage.Positive correlations between stage of disease with EMMPRIN,MMP-9 and VEGF were found（P 0.01,P =0.396）.The concentrations of VEGF after treatment were significantly lower（P 0.05） in plasma of endometriosis patients.Conclusion These results suggest that EMMPRIN,MMP-9 and VEGF may play an important role in the pathogenesis of the disease.Detection of EMMPRIN,MMP-9 and VEGF,especially VEGF in plasma of women with endometriosis has important clinical significance.