CD44分子在肾移植患者急性排斥反应肾组织中的表达及意义

Expression of CD44 in Acute Renal Allograft Rejection Renal Allograft

目的:探讨CD44分子与肾移植急性排斥反应的关系。方法:回顾分析2005年7月～2009年5月间肾移植术后穿刺病理活检证实为急性排斥反应患者28例的CD44在移植肾组织中的表达。结果:28例急性排斥反应肾组织中有25例CD44呈阳性表达,阳性率为89.29%;10例慢性排斥反应肾组织中有3例阳性表达,阳性率为30%;30例正常肾脏组织中5例CD44分子的阳性表达,阳性率为16.7%;两两比较,结果差异有统计学意义(P<0.05)。结论:CD44与其与配体的相互作用在移植肾急性排斥反应中可能起到重要作用,CD44分子有可能成为一个特异性和敏感性都较好的早期诊断急性排斥的预测因子。

Objective：To study the relationship between the renal graft expression of CD44 and the graft acute rejection. Methods：Retrospectively reviewed patients who had performed renal transplantation from 2005 to 2009 and identified 28 patients with acute renal rejection. The expression of CD44 of the graft was detected with immunohist-ochemical method. Results： The expression levels of graft with CD44 were significantly higher in acute renal rejection group than those in chronic renal rejection group and normal group. There were significant differences in the expression of CD44 in these groups. Conclusions： The expression of CD44 in grafts is correlated with clinical renal rejection, Examining the expression of CD44 in graft is helpful to the diagnosis and treatment of acute rejection in clinic. CD44 can be a high sensitivity and specificity predictor to acute rejection.