2007-2008年北京地区25～54岁已婚妇女宫颈上皮内瘤变的流行病学现状调查

Epidemiological study on the prevalence of cervical intraepithelial neoplasia among married women aged 25-54 years in Beijing between 2007-2008

目的 调查北京地区25～54岁已婚妇女宫颈上皮内瘤变（CIN）的患病现状.方法 采用横断面调查方法,于2007年3月至2008年9月,随机抽取北京地区12个区县共137个社区内25-54岁已婚妇女6339例（其中城区妇女942例,近郊区妇女3000例,远郊区妇女2397例）进行问卷调查、妇科检查、宫颈细胞涂片液基薄层细胞学检查（TCT）、宫颈分泌物高危型人乳头状瘤病毒-（HPV）检测,并对TCT结果异常者行阴道镜下宫颈活组织检查.结果 6339例妇女中,TCT结果异常者占9.58%（607/6339）;病理检查诊断为CIN者占5.84%（370/6339）,占TCT结果异常者的60.96%（370/607）,其中CIN Ⅰ为4.65%（295/6339）,CINⅡ为0.80%（51/6339）,CINⅢ为0.38%（24/6339）;早期浸润癌为0.06%（4/6339）.城区妇女宫颈病变的患病率为4.46%（42/942）,近郊区妇女为6.27%（188/3000）,远郊区妇女为6.01%（144/2397）,不同地区妇女宫颈病变的患病率比较,差异无统计学意义（P〉0.05）.结论 北京地区25～54岁已婚妇女CIN的患病率为5.84%,城区与近、远郊区妇女宫颈病变患病率无差异.

Objective To investigate prevalence of cervical intraepithelial neoplasia （CIN） among the married women aged 25-54 years in Beijing.Methods With method of cross sectional survey,6339 married women at age of 25 to 54 years were selected randomly in 137 communities of 12 districts or counties in Beijing from March 2007 to September 2008.The cervical smear cytology and high-risk human papillomavirus （HPV） infection of cervical secretion were detected.Women with abnormal cervical cytology were underwent colposcopy and cervical biopsy.Results Among 6339 women,9.58% （607/6339） cases had abnormal cytological results,the colposcopy and cervical biopsy showed the rate of CIN was 5.84% （370/6339） in total selected women and 60.96% （370/607） in women with abnormal cervical cytology,including 4.65% （295/6339） in CIN Ⅰ,0.80% （51/6339） in CIN Ⅱ,0.38% （24/6339） in CIN Ⅲ; 0.06% （4/6339）in early invasive carcinoma （SCC）.Based on geographical distribution,the rate of cervical lesions was 4.46% （42/942） in urban areas,6.27% （188/3000） in suburbs and 6.01% （144/ 2397） in outer suburbs （P 〉 0.05）.Conclusion It was found that the incidence of CIN was 5.84% in married women aged 25-54 years in Beijing,which did not show significant prevalence in urban,suburb and outer suburbs region.