男性冠心病患者血清睾酮与TF水平相关性研究

Research about Correlation between the Serum Levels of Testosterone and TF in the Male Patients with CHD

目的:观察不同类型男性冠心病患者血清睾酮、游离睾酮与组织因子(tissue factor,TF)水平改变及互相间相关关系,进一步探讨睾酮与TF在男性急性冠脉综合征(acute coronary syndrome,ACS)发病中的作用。方法:冠心病(coronary heart disease,CHD)患者分为急性心肌梗死(acute myocardial infarction,AMI)组、不稳定型心绞痛(unstable angina pectoris,UAP)组、稳定型心绞痛(stable angina pectoris,SAP)组,每组30例患者,另设健康对照组30例,比较各组间血清睾酮、游离睾酮与TF水平差异并分析其相关性。结果:AMI组和UAP组血清游离睾酮与TF水平与对照组比较差异有统计学意义(P<0.01),AMI、UAP患者血清游离睾酮与TF水平之间呈负相关(P<0.01)。结论:血清游离睾酮与TF水平改变与AMI、UAP的发生有关,它们可作为评价冠状动脉粥样硬化斑块稳定性与病变严重程度的一个参考指标。

Objective：To evaluate the peripheral levels of testosterone, free testosterone, TF and association between them in patients with different type of coronary heart disease, further more to understand the role testosterone and TF played in the pathogenesis of male ACS. Methods：For measuring serum concentrations of testosterone, free testosterone, and TF, three groups of 30 patients with acute myocardial infarction （AMI）, unstable angina pectoris （UAP）, and stable angina pectoris（SAP） and one equivalent group of 30 healthy volunteers（control group） were recruited. The serum levels of TF, testosterone and free testosterone were measured with ELISA method. Resuits： （1）The serum level of free testosterone in the patients with AMI,UAP was significantly lower, but of TF was notably higher than those in the control group （P〈0.01）. （2） Significant negative correlation between the serum levels of free testosterone and TF was observed in the patients with AMI,UAP（P〈0.01）. Conclusions： The alteration of serum concentrations of free testosterone and TF are associated with initiation and progression of AMI,UAP, and they may help evaluating stability of coronary atherosclerotic score and severity of disease.