联用微卡菌苗治疗耐多药肺结核的疗效分析

Effects of Mycobacterium vaccae vaccine on multi-drug resistant pulmonary tuberculosis

目的分析和评价联用母牛分枝杆菌菌苗(微卡菌苗)治疗耐多药肺结核(MDR-TB)的近远期疗效。方法将81例MDR-TB患者随机分为治疗组(A组,40例)和对照组(B组,41例)。2组的化疗方案均为3DLVKZ/15DLV,A组加用微卡菌苗治疗12月,B组不用微卡菌苗。结果疗程结束后,A组和B组痰菌阴转率分别为86.5%和58.5%,A组X线胸片显示病灶吸收、空洞缩小及关闭速度明显高于B组(P<0.05)。随访2年,A组和B组的痰菌复阳率分别为7.5%和14.6%。结论治疗组治疗耐多药肺结核病的近期和远期疗效明显高于对照组,且副作用小,值得推广应用。

Aim To observe and evaluate the short-term and long-term therapeutic effect of combined use of Mycobacterium vaccae vaccine （M. vaccae vaccine）on multi-drug resistant tuberculosis （MDR-TB）. Methods Eighty- one cases with MDR-TB were divided randomly into treatment group（Group A, with 40 eases） and control group（Group B, with 41eases）. The cases in two groups were treated by the same chemotherapy regimen of 3DLVKZ/15DLV. Patients in group A were treated with M. vaccae vaccine for twelve months and those in Group B were not given M. vaccae vaccine. Results At the end of the treatment,the sputum negtive comversion rates in Group A and B were 86.5% and 58.5%, respectively,and the chest X-ray （CXR）of Group A showed much higher speed in absorption of focus,as well as resolution and closure of holes（P〈0.05）. After a two-year follow-up survey, the sputum positive conversion rates were 7.5% in Group A and 14.6% in Group B. Conclusion The short-term and long-term therapeutic effects of combined use Of M. vaccae vaccine is effective for treatment of MDR-TB cases with less adverse reactions and worthy of application in clinical treament.