高频喷射通气对PE-SWD血气指标和前列腺素的影响

Effect of High Frequency Jet Ventilation on Indexes of Blood-gas and Prostaglandin in Pulmonary Edema after Seawater Drowning

观察高频喷射通气（HFJV）对海水淹溺肺水肿（PE-SWD）血气指标和前列腺素的影响，探讨HFJV的治疗机制。应用血气酸碱分析仪和XH－6010型γ放射免疫计数仪对兔动脉血气酸碱6项指标和前列腺素2项参数进行自动检测和定量测量，发现IIFJV组PaO2、SO2（血氧饱和度）、pH、AB实际碳酸氢盐）、BE（碱剩余）、和6－keto-PGF1α（6-酮-前列腺素F1α）均比PE－SWD组明显升高（P＜0．01或P＜0．05），HFJV组TXB2（血栓素B2）在灌海水后30min迅速上升随后呈下降趋势。但每项指标均未能恢复到灌海水前的水平。PaCO2两组之间无显著性差异。可见HFJV能较好地改善低氧血症，提高6－keto-PCF1α的浓度，而高浓度6-keto-PGFF1α具有支气管平滑肌松弛效应，对PaO2的回升有促进作用。

To approach the therapeutic mechanism of HFJV, the effect of HFJV on indexes of bloodgas and prostaglandin in PE-SWD was observed and analysed. Six indexes concerning blood-gas and acidbase and 2 derivatives of prostaglandin were assayed by the blood-gas analyser and XH-6010 automatic gama radioimmunity analyser. PaO2, SO2 (oxygen saturation), pH, AB(actual bicarbonate), BE(base excess) and 6-keto-PGF 1α in HFJV group were far higher than in PE-SWD group (P < 0. 01 or P <0.05). In HFJV group TXB2 rapidly increased at 30 min after seawater instillation, then dropped but these indexes didn' t recover to normal level before instillation. There was not significant difference of PaCO2 between PE-SWD group and HFJV group. HFJV therapy may improve hypoxemic conditions, and increase the conocentration of 6-keto-PGF 1α. The high concentration of 6-keto-PGF 1α produces relaxing effect on omooth musele of the bronchus, and helps PaO2 level rise.