呕吐毒素不同给药方式对猪血常规指标的影响

Influence of Deoxynivalenol on Hematologic Indexes by Different Administration Methods in Pigs

呕吐毒素(vomitoxin,VT)是目前全球谷物污染最严重的真菌毒素之一,易感动物中以猪最为敏感。本研究以呕吐毒素标准品为原料,通过灌胃和静脉注射2种给药途径,研究该毒素对猪体内血常规指标的影响。结果表明,灌喂组血常规检测值中,猪血红细胞压积(HCT)在12、24 h时极显著低于给药前(P<0.01);血红蛋白(HGB)、血红细胞压积(HCT)均低于给药前,在0.33、1、2 h时显著低于给药前(P<0.05);红细胞数(RBC)、血小板(PLT)总数与给药前相比无显著差异(P>0.05)。注射组中,白细胞数(WBC)、红细胞数(RBC)、血小板(PLT)数与给药前相比无显著差异(P>0.05);血红细胞压积(HCT)、血红蛋白(HGB)均低于给药前,分别在0.170、.33 h显著低于给药前(P<0.05),在其它时间点,血红细胞压积和血红蛋白则均极显著低于给药前(P<0.01)。呕吐毒素不同给药方式对猪血常规指标无显著影响(P>0.05)。

Deoxynivalenol（DON,vomitoxin） contamination of grains is a very common phenomenon in the global.The pigs are most susceptible to DON.The research studies pharmacokinetic of deoxynivalenol and clinical normal indexes of hematology and biochemistry by intragastric and intravenous（IV） administration of pure DON.The results showed that HCT had very significant difference in 12,24 h compared with pre-administration（P〈0.01）;HGB and HCT were lower than pre-administration,and had significant difference in 0.33,1,2 h compared with pre-administration（P〈0.05）;RBC and PLT had no difference compared with pre-administration（P〉0.05）.In intravenous group,WBC,RBC and PLT had no difference compared with pre-administration（P〉0.05）;WBC,RBC and PLT were lower than pre-administration,and had significant difference in 0.17,0.33 h compared with pre-administration respectively（P〈0.05）;HCT and HGB had very significant difference compared with pre-administration at other times（P〈0.01）.Hematologic indexes had no difference effects of vomitoxin by different administration methods in pigs（P〉0.05）.