噻肟单酰胺菌素治疗尿路感染的临床观察

Treatment of urinary tract infection with primbactin

目的：观察噻肟单酰胺菌素治疗尿路感染的临床疗效和安全性．方法：选择尿路感染病例114例，随机分成2组；治疗组60例（男11例，女49例，年龄（43±15岁），其中复杂性尿路感染病人24例．对照组54例（男12例、女42例，年龄（41±15岁），其中复杂性尿路感染13例．治疗组给予噻肟单酰胺菌素1．2-2.0g加入生理盐水中250ml中静滴，一日2次，疗程7-14d．对照组给予丁胺卡那霉素0．2g加入生理盐水250ml中静滴，一日1次，疗程7－14d．结果：治疗组总有效率63．3％，对照组总有效率64．8％，治疗组疗效明显优于对照组（P＜0.05）．结论：噻肟单酰胺菌素治疗尿路感染，特别是上尿路感染疗效好，安全性高．

To observe the efllciency and sattty of primbactin for urineq tract infections, 114 casses of urinarytract infection were randomly divided into two groups. 60 patients (M 11, F49, age 43 ±15) including thecomplex 24 casses of complex urinary tract infection receved primbactin 1.0~2.0 in 250ml of 0.9% sodiumchloride injectons, iv,drip, Bid. for 7~14d; The other 54 patients as control (M 12, F 42, ages 41 ± 15) including17 casses of complex urineq tract infection received amikacin 0.2 in 250ml of 0.9% sodium chloride injections,iv, drip, Bid, for 7~14d. The total effective rate was 83.3% in the therapy group and 64.8% in the control group,with significant difference (P<0.05)- Theretbre, primbactin is an effective and safe antibioticl in treating urinarytract infection, especially upper urinary tract infection.