尘螨Ⅱ类变应原研究进展

Research progress on the group 2 allergen of house dust mites

尘螨是最常见的室内变应原之一，其最主要的变应原是Ⅰ类变应原和Ⅱ类变应原。该文从尘螨Ⅱ类变应原的研究概况、在螨体内的定位、结构和生化特性研究与同源性和多态性分析、螨性过敏性疾病的致病机制及其疫苗研究等方面进行了综述。

House dust mite is one of the most common and important indoor allergens. Group 1 and 2 allergens are two major allergens of house dust mites. This article reviewed the research progress on group 2 allergen, its localization in the body of house dust mites, structure and biochemical characteristics, homology and polymorphism, the mechanism of house dust mite allergy, the importance of the allergen and development of vaccine etc..