摘要
探讨低剂量电离辐射对小鼠特异性抗体产生是否有影响。方法昆明种雄性小鼠单次照射60Coγ射线后,用狂犬疫苗全程免疫,ELISA法测定小鼠狂犬病毒特异性IgG抗体水平。结果①5~30cGyγ射线照射的小鼠血清中特异性抗体水平显著高于对照,其中10cGy为刺激血清特异性抗体产生的最佳剂量;②10cGy照射,小鼠血清中特异性抗体水平的峰值显著高于对照组的峰值,而且其峰值提前出现;③10cGy照射引起的特异性抗体水平的增高可持续1周。结论低剂量电离辐射可对小鼠血清特异性抗体的产生有刺激作用,并可持续一定的时间。
Objective\ To explore the effect of low dose ionizing radiation on specific antibody in mouse serum.Methods\ Kunming strain male mice,weighing 18 22 g,aged 6 8 weeks,were immunized intraperitoneally with rabies vaccine after exposure to cobalt 60 γ rays.The specific IgG antibody against rabies virus in mouse serum was measured.Results\ (1)The serum levels of specific IgG in mice irradiated with 5 30 cGy γ rays were significantly elevated in comparison with those in control mice ( P <0 01),the optimum stimulating dose being 10 cGy.(2)Exposure to 10 cGy caused significant enhancement and earlier emergence of the peak level of specific IgG in serum.(3)The hormesis of specific IgG to rabies virus induced by 10 cGy γ rays could last one week at least.Conclusion\ Low dose ionizing radiation can enhance the level of specific antibody in mouse serum,and this effect can last for one week at least.
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
1998年第6期403-405,共3页
Chinese Journal of Radiological Medicine and Protection
关键词
免疫刺激
低剂量辐射
小鼠
狂犬病毒
特异性IGG
Humoral immune hormesis\ \ Low dose γ rays\ \ Mice\ \ Rabies virus Specific IgG