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RNA在生物学的重要地位及其作为常规治疗药物的研究进展 被引量：1

The central role of RNA in biology and as a general therapeutic agent
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摘要 20多年来的研究发现,RNA除了具有如tRNA、rRNA参与蛋白质生物合成的基本功能外,细胞内还存在许多种类的RNA,它们执行着不同的功能,在细胞内生物化学反应及机体发育调控过程中发挥着重要作用。正因为RNA功能多样性,在体内、体外开展的众多实验表明,RNA或其修饰形式可以抑制基因的表达。该文将探讨RNA在常规基因治疗中的研究。 The diverse roles of different RNA molecules discovered over the past 20 years show the importance in intracellular biochemistry and in the regulation of developmental events in vivo.These novel functions of RNA are in addition to the basic roles of tRNA and rRNA in protein synthesis.RNA,or modified versions thereof,can be shown to inhibit the expression of genes in vitro or in vivo.A new function of RNA in general gene therapy will be discussed.
作者 Sidney Altman 胡庆华
机构地区 美国耶鲁大学分子细胞和发育生物学系 中国科学院上海生物化学和细胞生物学研究所
出处 《生命科学》 CSCD 北大核心 2010年第3期216-223,共8页 Chinese Bulletin of Life Sciences
关键词 核糖核酸 功能多样性 核糖核酸酶P 基因治疗 RNA diverse functions RNase P gene therapy
分类号 Q521 [生物学—生物化学] Q814 [生物学—生物工程]
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同被引文献18

  • 1He K, Wang P. Unregulated long non- coding RNA- AK058003 promotes the proliferation, invasion and metastasis of breast cancer by regulating the expression levels of the γ-synuclein gene [ J ]. Exp Ther Med. , 2015, 9(5):1727-1732.
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生命科学
2010年 第3期

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