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MicroRNA与膀胱癌 被引量：2

MicroRNA and bladder cancer
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摘要 MicroRNA(miRNA)是一类21～23个核苷酸长度的单链非编码小分子RNA,在转录后水平调节基因表达,从而实现对组织发生、个体发育及肿瘤发生等生理病理过程的调节作用。膀胱癌是国人泌尿系统中最常见的肿瘤。研究表明,miRNA参与了膀胱癌的发生、发展,一些差异表达miRNA有望成为膀胱癌诊断、治疗的靶点。该文就miRNA在膀胱癌发病机理、诊断、治疗等方面的研究进展作一综述。 MicroRNAs（miRNAs） are 21-23nt regulatory,non-coding RNAs that are thought to control gene expression at the post transcriptional level.It was reported that miRNAs regulate a wide range of biological and pathological processes,including histogenesis,development and tumorigenesis.Bladder cancer is the most common urinary cancer in China.Growing evidences suggested that miRNAs were involved in the processes of bladder cancer carcinogenesis and progression.Some differential expressed miRNAs might serve as potential targets for bladder cancer diagnosis and treatment.This article reviews the current knowledge about the role of miRNAs in bladder cancer carcinogenesis,their potential role in improving diagnosis and therapeutics.
作者 王刚
机构地区 浙江杭州市第一人民医院泌尿外科
出处 《生命科学》 CSCD 北大核心 2010年第3期262-266,共5页 Chinese Bulletin of Life Sciences
基金 浙江省杭州市科技局重点资助项目(200432959)
关键词 MIRNA 膀胱癌 发病机理 诊断 治疗 miRNA bladder cancer pathogenesis diagnosis treatment
分类号 Q522 [生物学—生物化学] R737.14 [医药卫生—肿瘤]
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参考文献21

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同被引文献50

  • 1蒋海锋,薄隽杰.MicroRNA与膀胱癌的研究进展[J].中国癌症杂志,2011,21(4):308-312. 被引量：4
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  • 6Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A ,2004,101:2999-3004.
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生命科学
2010年 第3期

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