胃肠道外营养的新生儿血清TBA、CG、HA水平变化及临床意义

Clinical Significance of Changes of Serum TBA,CG,HA Levels in Neonate with Parenteral Nutrition

目的:探讨胃肠道外营养的新生儿血清总胆汁酸(TBA)甘胆酸(CG)及透明质酸(HA)水平变化及临床意义。方法:52例行胃肠道外营养的新生儿(足月儿32例,早产儿20例)作为观察组,28例无需胃肠道外营养的新生儿作为对照组(足月儿16例,早产儿12例)。采用酶速率法和放射免疫分析测定胃肠道外营养前后TBA、CG、HA水平变化,比较足月儿与早产儿三项水平变化的差别。结果:足月儿胃肠道外营养前TBA、CG、HA水平与对照组比较,差异无显著性(P>0.05);胃肠道外营养后TBA、CG、HA水平较胃肠道外营养前明显升高,差异有非常显著性(P<0.01);早产儿胃肠道外营养后TBA、CG、HA水平较足月儿明显升高,差异有显著性(P<0.05)。结论:胃肠道外营养对新生儿肝胆系统功能有影响,且以早产儿为明显。

Objective To study the clinical significance of changes of serum levels of TBA,CG,HA in neonate with parenteral nutrition. Methods Serum total bile acid （TBA,with biochemistry） and CG,HA （with RIA） contents were measured in 52 neonates （full-term 32,preterm 20） with parenteral nutrition and 28 neonates （full-term 16,preterm 12） without parenteral nutrition （as controls）. Results Before parenteral nutrition,the serum TBA,CG and HA levels in full-term neonates were not significantly different from those in the controls （P0.05）. After parenteral nutrition,serum levels were significantly higher than those before parenteral nutrition （P0.01）. The levels in pre-term neonates were significantly higher after parenteral nutrition than those in full-term neonates （P0.05）. Conclusion Long term parenteral nutrition might be harmful to hepatic and gall bladder function in neonates especially in premature ones.