急性肾炎患儿治疗前后血清hs-CRP、IL-2、IL-6和GM-CSF检测的临床意义

Clinical Significance of Determination of Serum hs-CRP,IL-2,IL-6 and GM-CSF Levels After Treatment in Pediatric Patients with Acute Nephritis

目的:探讨了小儿急性肾炎患儿治疗前后血清CRP、IL-2、IL-6和GM-CSF水平的变化及意义。方法:应用放射免疫分析和免疫比浊法对31例急性肾炎患儿进行了治疗前后血清hs-CRP、IL-2、IL-6和GM-CSF测定并与35名正常儿作比较。结果:在治疗前,急性肾炎患儿血清hs-CRP、IL-6和GM-CSF水平非常显著的高于正常儿组(P<0.01),而IL-2水平又非常显著地低于正常儿组(P<0.01),经治疗1个月后则与正常儿比较无显著性差异(P>0.05),直线相关分析显示,血清IL-2水平、hs-CRP、IL-6和GM-CSF水平呈明显负相关(r=-0.5678、-0.6014、-0.5926,P<0.01)。结论:血清hs-CRP、IL-2、IL-6和GM-CSF在急性肾炎患儿的发生和发展过程中相互作用,观察其病情的变化和探讨其发病机理及指导用药均有重要的临床价值。

Objective To explore the clinical significance of determination of serum hs-CRP,IL-2,IL-6 and GM-CSF levels after treatment in pediatric patients with acute nephritis. Methods Serum hs-CRP （with immuno-turbidity method）,IL-2,IL-6 and GM-CSF （with RIA） levels were determined both before and after treatmant in 31 pediatric patients with acute nephritis and 35 controls. Results Before treatment,the serum hs-CRP,IL-6 and GM-CSF levels were significantly higher in the patients than those in controls（P0.01）,but serum IL-2 levels were significantly lower in the patients（P0.01）. After treatment for one month the serum hs-CRP,IL-2,IL-6 and GM-CSF levels in patients were not significantly different from those in controls （P0.05）. Serum IL-2 levels were negatively correlated with the hs-CRP,IL-6 and GM-CSF levels （r=-0.5678,-0.6014,-0.5926,P0.01）. Conclusion These cytokines participated in the pathogenesis of acute nephritis in pediatric patients. Mornitoring the changes of their serum levels was helpful for the management of the diseases.