摘要
To investigate changes of functional activation areas of the cerebral cortex and the connectivity of motor cortex networks （MCNs） in stroke patients during the recovery, five patients with the infarct in their left hemispheres are recruited. Functional magnetic resonance imaging （fMRI） is performed in the second, fourth, eighth, and sixteenth weeks after the stroke. Images are analyzed using the professional software SPM5 to obtain the bilateral activation of the motor cortex in left and right handgrip tests. MCN data are extracted from the active areas, and the structural and functional characteristic parameters are computed to indicate the connectivity of the network. Results show that the ipsilesional hemisphere recruits more areas with less active extent during the handgrip test, compared with the contralesional hemisphere. MCN shows a higher overall degree of statistical independence and more statistical dependence among motor areas with the gradual recovery. It can help physicians understand the recovery mechanism.
为了了解中风患者康复期间大脑皮层功能激活区和运动皮层网络连通性的变化,以5名左侧大脑皮层有病变的患者为研究对象,在其发病后的第2,4,8和16周进行功能磁共振检查。利用SPM5软件对患者左、右手握拳任务下的图像进行分析,得到大脑运动皮层激活图。利用激活区域提取大脑运动皮层网络并计算其结构和功能特征以反映网络连通性。研究结果显示,在握拳任务下,损伤侧大脑半球与非损伤侧大脑半球相比,具有较多的激活区和较低的激活程度;运动皮层网络随着患者的逐渐康复表现出整体上较强的独立性和运动区域间较强的依赖性。研究有助于理解康复的机制。
基金
Supported by the National Natural Science Foundation of China (30670543)~~
