接受抗病毒药物治疗艾滋病患者体内病毒数量变化研究

Study of Viral Load Variance in 32 AIDS Patients Accepted Highly Active Antiretroviral Therapy

目的观察抗病毒药物治疗艾滋病患者体内病毒数量变化情况,从而评价治疗效果。方法32例接受HAART的艾滋病人于治疗0、6、12、18和24个月HIV病毒载量进行检测,并进行随访调查。结果接受治疗的艾滋病人治疗0个月和治疗后病毒载量差异有统计学意义,而治疗后各个时间点的病毒载量差异无统计学意义。治疗后大部分病人的病毒载量水平低于检测下限,依从性差和耐药对病毒下降有影响。结论大部分艾滋病人接受国家抗病毒药物治疗的效果明显,但随着治疗时间延长,病毒数量有反弹现象,值得关注。

Objective To observe the variance of viral load in AIDS patients accepted highly active antiretroviral therapy,and to value the effect of therapy.Methods The viral load of HIV was detected in 32 AIDS patients accepted HARRT at 0,6,12,18 and 24 months after therapy,and then a follow-up investigation was carried out.Results The viral load in AIDS patients had statistically significant differences between before therapy and after therapy,but no statistically significant difference was found in the viral load in all time spots after therapy.The level of viral load in most patients after therapy was below the low limit of detection,and the poor compliance and drug-resistance had effects on the decline of the viral load.Conclusions The effect of HAART is significant in most AIDS patients,but the level of viral load appears rebound phenomenon as the time of the therapy prolonging.It is worth paying attention to.