白介素-1基因与中国人散发性帕金森病的关系

Relationship Between Interleukin-1 Gene and Chinese Sporadic Parkinson's Disease

目的探讨白介素-1受体拮抗剂基因(IL-1RA)及白介素-1β基因多态性与帕金森病(PD)的关系。方法本实验用PCR-片段长度多态性分析法检测了89例中国散发性帕金森病病人和67例正常对照的IL-1RA基因串联重复序列(VNTR)和IL-1β基因多态性。结果IL-1RAVNTR基因多态性在散发性PD组与正常对照组之间差异无统计学意义(P>0.05),IL-1RAVNTR基因多态性在帕金森病合并痴呆亚型(PDD组)和非痴呆亚型(PDND组)之间差异有统计学意义(P<0.05);IL-1β基因C-511T多态性在散发性PD组与正常对照组之间差异有统计学意义(P<0.05),但IL-1β基因C-511T多态性在PDD组和PDND组之间差异无统计学意义(P>0.05)。结论提示IL-1RA基因多态性可能与我国人散发性帕金森病的发病无关,而与帕金森病并发痴呆发病过程中有关;IL-1β可能是散发性帕金森病的易感基因之一。

Objective To explore the relationship between interleukin-1 receptor antagonist （IL-1RA） and interleukin-1β genetic polymorphism with sporadic Parkinson’s disease （PD）.Methods IL-1RA and interleukin-1β genetic polymorphisms in 89 sporadic PD patients and 67 healthy controls were analyzed with the polymerase chain reaction restriction fragment length polymorphism （PCR-RFLP） technique.Results No statistically significant difference was found in IL-1RA genetic polymorphism between PD group and control group （P0.05）,but there were statistically significant differences in IL-1RA genetic polymorphism between PD with dementia group （PDD） and PD without dementia group （PDND）,（P0.05）.There were statistically significant differences in interleukin-1β （C-511T） genetic polymorphism between PD and control groups （P0.05）,but no statistically significant difference was found in interleukin-1β （C-511T） genetic polymorphism between PDD group and PDND group （P0.05）.Conclusions The results suggest that IL-1RA genetic polymorphism may not be related to the pathogenesis of sporadic PD,but may be related to the pathogenesis of PDND.The IL-1β may be one of the susceptible genes for sporadic PD.