抗炎灵对重度烧伤后全身炎症反应综合征和多器官功能不全综合征的作用

Effect of traditional chinese medicine on SIRS and MODS after burn

目的探讨抗炎灵在防治重度烧伤后全身炎症反应综合征(SIRS)和多器官功能不全综合征(MODS)中的作用机制。方法重度烧伤患者36例,随机分为抗炎灵组和对照组,每组18例;抗炎灵组加用抗炎灵汤剂,其他治疗与对照组相同;分别观察烧伤后SIRS和MODS的发生率,检测第1、3、7、10、14天血清中LPS、TNF-α、IL-6、IL-8的含量。结果对照组SIRS和MODS发生率明显高于抗炎灵组(P<0.05),两组血清中LPS、TNF-α、IL-6、IL-8含量均高于正常值,第1天两组间无统计学意义(P>0.05),第3天以后抗炎灵组上述各指标均有明显下降(P<0.05)。结论抗炎灵通过降低血清中LPS、TNF-α、IL-6和IL-8的含量,抑制炎症介质的释放,减轻炎症反应,从而有效防治烧伤后SIRS和MODS的发生。

Objective To study the therapeutic effect of traditional Chinese medicine（TCM）（an anti-inflammation agent） on systemic inflammatory response syndrome（SIRS） and multiple organ dysfunction syndrome（MODS）（SIRSMODS） after burn.Methods Thirty-six burn patients were divided randomly into control group and TCM group（n=18 per group） after admitted to the hospital.The incidence of SIRSMODS was observed.Plasma levels of tumor necrosis factor-alpha（TNF-α）,interleukin（IL）-6,and IL-8 were determined by ELISA,and LPS was measured by an endotoxin-specific synthetic substrate method on the lst,3rd,7th,10th and 14th dag after they were burned.Results The incidence of SIRSMODS was higher in the control than in the TCM group（P0.05）.Plasma levels of LPS,TNF-α,IL-6,and IL-8 increased after burn in both the groups,but they decreased more significantly in the TCM group than in the control group since the 3rd day（P0.05）.Conclusion TCM can ease inflammatory response and treat SIRSMODS after burn through bringing down plasma levels of LPS,TNF-α,IL-6 and IL-8 and inhabiting the release of inflammatory media.